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X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20240331T010000
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DTSTART;TZID=Europe/Paris:20240612T150000
DTEND;TZID=Europe/Paris:20240612T170000
DTSTAMP:20260408T033158
CREATED:20240314T110338Z
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UID:170018-1718204400-1718211600@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Giuseppe Gangarossa
DESCRIPTION:Venue: CGFB \n\nGiuseppe Gangarossa\nProfessor of Neurobiology of Homeostasis\nUniversité Paris Cité \nInvited by Victor Jouque and Daniela Cota (Magendie) \nTitle\nThe paraventricular thalamus: a new player in the control of feeding behaviours and energy balance \nAbstract\nThe paraventricular thalamus (PVT) has recently emerged as a critical hub involved in the regulation of cognitive processes but also in the integration of homeostatic and visceral signals\, thus controlling adaptive and food-seeking behavioural responses. However\, despite growing evidence\, the neural mechanisms by which the PVT gates feeding\, energy balance and nutrients partitioning remain largely unknown. \nHere\, we show that catecholaminergic projections from the hindbrain to the PVT and a specific subpopulation of PVT-neurons\, notably those expressing the dopamine D2 receptors\, promptly and bidirectionally gate feeding behaviours\, body homeostasis and energy balance\, thereby contributing to the control of energy-related adaptive responses in both physiological and obesogenic contexts. In addition\, by combining complementary cutting-edge strategies (cell-type specific chemogenetics\, ex vivo and in vivo neuronal dynamics) to functional behavioural and metabolic readouts\, we describe PVT D2R-neurons as gatekeepers of hunger and satiety. \n\nThese results may lead to a new understanding of unconventional brain circuits involved in food-related disorders and may provide new therapeutic solutions to counterbalance obesity-associated dysfunctions. \nRecent publications\nCastel et al.\, 2024 (Mol Psychiatry\, PMID: 38361126)\nDumont et al.\, 2022 (J Physiol\, PMID: 35648134)\nBerland et al.\, 2022 (Mol Psychiatry\, PMID: 35075269)\nBerland et al.\, 2021 (Trends Endocrinol Metab\, PMID: 34148784)\nBerland et al.\, 2020 (Cell Metab\, PMID: 32142669) \n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-giuseppe-gangarossa/
CATEGORIES:For scientists,home-event,Impromptu seminar
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