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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20250330T010000
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DTSTART:20251026T010000
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DTSTART;TZID=Europe/Paris:20251118T110000
DTEND;TZID=Europe/Paris:20251118T110000
DTSTAMP:20260501T162524
CREATED:20251104T164339Z
LAST-MODIFIED:20251110T184954Z
UID:189260-1763463600-1763463600@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Gian-Carlo Bellenchi
DESCRIPTION:Venue: Centre Broca \n\nGian-Carlo Bellenchi\nInstitute of Biochemistry and Cell Biology IBBC-CNR\,\nMonterotondo\, Rome\, Italy.\nSanta Lucia Foundation IRCCS\, Rome\, Italy. \nInvited by Etienne Herzog (IINS) \nTitle\nThe Contribution of microRNAs to the Development and Function of Dopaminergic Neurons \nAbstract\nThe development and function of midbrain dopaminergic neurons (DAn) rely on tightly coordinated molecular programs involving both transcriptional and post-transcriptional regulation. While morphogens and transcription factors are well-established drivers of DAn specification\, the contribution of microRNAs (miRNAs) to these processes has only recently begun to emerge. Using paired miRNA–mRNA profiling during dopaminergic differentiation\, we identified miR-34b/c and miR-218 as key post-transcriptional regulators shaping DAn identity and function. miR-34b/c promotes dopaminergic lineage commitment and differentiation during embryonic development\, at least in part through modulation of Wnt1 signaling. In parallel\, miR-218 facilitates the functional maturation of DAn\, and its conditional deletion alters the expression of synaptic-related transcripts\, disrupts intrinsic excitability\, and reduces stimulus-evoked dopamine release. Together\, these findings highlight miRNA–mRNA co-regulatory networks as integral components of dopaminergic neuron development and physiology\, and position miRNAs as essential hubs orchestrating dopaminergic differentiation and neurotransmission. \nRelated Articles\nPulcrano S\, et al. miR-218 Regulates the Excitability of VTA Dopamine Neurons and the Mesoaccumbens Pathway in Mice. Brain Sci. 2025 \nTaylor SR\, et al. MicroRNA-218 instructs proper assembly of hippocampal networks. Elife. 2023 \nPulcrano S\, et al. miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network. J Neurosci. 2023 \nPulcrano S\, et al.  Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation. Int J Mol Sci. 2022 \nDe Gregorio R\, et al. miR-34b/c Regulates Wnt1 and Enhances Mesencephalic Dopaminergic Neuron Differentiation. Stem Cell Reports. 2018 \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-gian-carlo-bellenchi/
CATEGORIES:For scientists,home-event,Impromptu seminar
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