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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
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DTSTART:20190331T010000
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DTSTART:20191027T010000
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20190315T113000
DTEND;TZID=Europe/Paris:20190315T123000
DTSTAMP:20260408T164620
CREATED:20190125T151913Z
LAST-MODIFIED:20191030T154806Z
UID:102564-1552649400-1552653000@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Charles Nicholson
DESCRIPTION:\n	\n		\n			Venue: Centre Broca Nouvelle Aquitaine / Conference room  \nCharles Nicholson\nProfessor Emeritus\, New York University School of Medicine \nInvited by :  Valentin Nägerl / Laurent Cognet / Laurent Groc\,\nIIINS \n\n  \n\n\n		\n	\n”Abstract”\n\n	\n		\n			\nBrain extracellular space (ECS) is the narrow microenvironment that surrounds every cell of the central nervous system. Attempts to reveal the size and structure of the ECS using electron microscopy have had limited success; however\, a biophysical approach based on diffusion of selected probe molecules over distances of 10 – 100 micrometers has proved useful. This approach has shown that the ECS occupies approximately 20% of brain tissue and small molecules have an effective diffusion coefficient that is two-fifths that in a free solution. Monte Carlo modeling indicates that geometrical constraints\, including dead-space microdomains\, contribute to the hindrance to diffusion. Imaging the spread of macromolecules shows them increasingly hindered as a function of size and suggests that the gaps between cells are predominantly approximately 40 nanometers with wider local voids that may represent dead-spaces. Diffusion measurements also characterize interactions of substances with the extracellular matrix. it appears that the size of the ECS changes in going from the sleeping to waking state and this may have implications for the removal of waste substances from the brain as a component of the glymphatic system. \n\n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-charles-nicholson/
LOCATION:Centre Broca Nouvelle-Aquitaine\, 38 Rue Albert Marquet\, Bordeaux\, 33000\, France
CATEGORIES:home-event,Seminars
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