BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Bordeaux Neurocampus - ECPv4.9.10//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20231029T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20231215T113000
DTEND;TZID=Europe/Paris:20231215T113000
DTSTAMP:20260410T141904
CREATED:20230509T073518Z
LAST-MODIFIED:20231206T214220Z
UID:159367-1702639800-1702639800@www.bordeaux-neurocampus.fr
SUMMARY:Monthly conference (PhD seminar) - René Hen
DESCRIPTION:Venue: Centre Broca Nouvelle-Aquitaine \n\nRené HEN\nColumbia University\, New York\, USA \nInvited by Nicolas Blin (Abrous’ Lab – Magendie) \nTitle\n\nAdult Hippocampal neurogenesis\, pattern separation\, and overgeneralization \nAbstract\nAdult born granule cells (abGCs) have been implicated in memory discrimination through a neural computation known as pattern separation. We have examined how chronic ablation or acute chemogenetic silencing of abGCs affects the activity of mature granule cells (mGCs) using in vivo Ca2+ imaging. In both cases we observed altered remapping of mGCs. Rather than broadly modulating the activity of all mGCs\, abGCs promote the remapping of place cells’ firing fields while increasing rate remapping of mGCs representing sensory cues. In turn\, these remapping deficits are associated with behavioral impairments in animals’ ability to correctly identify new goal locations. Thus\, abGCs facilitate pattern separation through the formation of non-overlapping representations for identical sensory cues encountered in different locations. In the absence of abGCs the dentate gyrus shifts to a state dominated by cue information\, a situation that is consistent with the overgeneralization often observed in anxiety or age related disorders. \nPublications\nTuncdemir SN\, Grosmark AD\, Chung H\, Luna VM\, Lacefield CO\, Losonczy A\, and Hen R. Adult born granule cells facilitate remapping of spatial and non-spatial representations in the dentate gyrus. 2023\, Neuron. In press (online\, Oct 10). \nStefanini F\, Kushnir L\, Jimenez JC\, Jennings JH\, Woods NI\, Stuber GD\, Kheirbek MA\, Hen R\, Fusi S. (2020) A Distributed Neural Code in the Dentate Gyrus and in CA1.  Neuron.107(4):703-716. \nLuna VM\, Anacker C\, Burghardt N\, Khandaker H\, Andreu V\, Millette A\, Leary P\,\nRavenelle R\, Jimenez J\, Mastrodonato A\, Denny CA\, Fenton A\, Scharfman H\, Hen R. (2019); Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus. Science. 364(6440):578-583. \n\nPhD seminars are organized by the NBA\, Bordeaux Neurocampus\, and the Bordeaux Neurocampus Graduate Program \n
URL:https://www.bordeaux-neurocampus.fr/en/event/phd-seminar-rene-hen/
CATEGORIES:For scientists,home-event,Monthly conferences
END:VEVENT
END:VCALENDAR