BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Bordeaux Neurocampus - ECPv4.9.10//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20270328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20271031T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20270521T113000
DTEND;TZID=Europe/Paris:20270521T113000
DTSTAMP:20260926T032024
CREATED:20260707T161039Z
LAST-MODIFIED:20260922T133303Z
UID:204242-1810899000-1810899000@www.bordeaux-neurocampus.fr
SUMMARY:PhD seminar - Harold Mac Gillavry
DESCRIPTION:Venue: Centre Broca \n\nHarold Mac Gillavry\nAssociate Professor\nCenter for Neurogenomics and Neurocognitive Research (CNCR)\nAmsterdam\, NL\nhttps://research.vu.nl/en/persons/harold-mac-gillavry/ \nInvited by Tanuj Arora (IINS) \nTitle\nResolving the dynamic nano-architecture of excitatory synapses \nAbstract\nNeuronal synapses are composed of a diverse array of protein complexes that are essential for synaptic transmission and plasticity. However\, although many synaptic complexes have been characterized extensively\, it is unknown how these constituents are assembled within synapses to efficiently control synaptic transmission. We investigate the mechanisms that control the dynamic molecular organization of neuronal synapses. By combining molecular biology\, super-resolution imaging\, and functional approaches\, we aim to understand how synaptic proteins are organized\, how this organization changes in response to neuronal activity\, and how molecular architecture is linked to the regulation of synaptic transmission. I will highlight recent and ongoing work from the lab to illustrate how studying synapses at increasingly high resolution helps revealing fundamental principles of synapse biology. \nKey publications\n\nMacGillavry HD\, Song Y\, Raghavachari S\, Blanpied TA. (2013) Nanoscale scaffolding domains within the postsynaptic density concentrate synaptic AMPA receptors. Neuron.\nWillems J*\, De Jong APH*\, Scheefhals N\, Mertens E\, Catsburg LAE\, Poorthuis RB\, De Winter F\, Verhaagen J\, Meye FJ\, and MacGillavry HD (2020) ORANGE: A CRISPR/Cas9-based genome editing toolbox for epitope tagging of endogenous proteins in neurons. PLOS Biology\nCatsburg LA\, Westra M\, van Schaik AM\, MacGillavry HD (2022) Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatorysynapses. Elife\nBodzęta A\, Berger F\, MacGillavry HD (2022) Subsynaptic mobility of presynaptic mGluR types is differentially regulated by intra- and extracellular interactions. Mol Biol Cell.\nScheefhals N\, Westra M\, and MacGillavry HD (2023) mGluR5 is transiently confined in perisynaptic nanodomains to shape synaptic transmission. Nature Communication\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/phd-seminar-harold-mac-gillavry/
CATEGORIES:For scientists,home-event,Monthly conferences
END:VEVENT
END:VCALENDAR