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X-WR-CALNAME:Bordeaux Neurocampus
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X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART;TZID=Europe/Paris:20200414T140000
DTEND;TZID=Europe/Paris:20200414T150000
DTSTAMP:20260503T053348
CREATED:20200303T085403Z
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UID:117545-1586872800-1586876400@www.bordeaux-neurocampus.fr
SUMMARY:Cancelled // Impromptu seminar - Simon Dujardin
DESCRIPTION:Venue: Centre Broca Nouvelle-Aquitaine \n\nSimon Dujardin\, PhD\nDepartment of Neurology\, Harvard Medical School\,\nMassachusetts General Hospital\,\nMassGeneral Institute for Neurodegenerative Disease \nInvited by Erwan Bezard \n\nPathophysiological propagation of Tau: from cell-to-cell transfer to seeding of pathology; how do we move forward?\nThe hyperphosphorylation and deposition of tau proteins in insoluble aggregates inside neurons are a hallmark of around 20 pathologies called tauopathies including the well-known Alzheimer’s disease (AD). In AD and a number of other tauopathies\, histopathological studies have shown that tau lesions appear progressively and hierarchically in the brain along anatomical connections. The mechanisms underlying such evolution had remained unexplained for many years\, but recent evidence support the idea that the evolution across brain areas is the result of the active propagation of tau aggregation within the brain. We and others demonstrated in in vitro and in vivo models that tau assemblies are indeed transferred from cell-to-cell and\, by being taken up by a second cell\, are able to seed the aggregation of endogenous tau leading to the propagation of tau lesions in the brain. In this talk we will discuss what is known about the mechanisms of tau propagation and seeding and its implication in the human Alzheimer’s disease pathology. We will also talk about how 1-the biochemical properties of different tau species and 2- the genetic background influence tau propagation mechanisms as well as the current challenges and pitfalls in the field. \n
URL:https://www.bordeaux-neurocampus.fr/en/event/impromptu-seminar-simon-dujardin/
CATEGORIES:For scientists,home-event,Impromptu seminar
ATTACH;FMTTYPE=image/jpeg:https://www.bordeaux-neurocampus.fr/wp-content/uploads/2020/03/duajrdin-simon-vignette.jpg
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