BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Bordeaux Neurocampus - ECPv4.9.10//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20200329T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20201025T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20200115T110000
DTEND;TZID=Europe/Paris:20200115T130000
DTSTAMP:20260313T203352
CREATED:20200106T105918Z
LAST-MODIFIED:20200108T094116Z
UID:114299-1579086000-1579093200@www.bordeaux-neurocampus.fr
SUMMARY:Impromptu seminar - Andre Kleinridders
DESCRIPTION:Venue: Centre Broca \n\nBrain insulin signaling plays a key role in metabolism and mental health \nAndre Kleinridders\nGerman Institute of Human Nutrition \nInvited by Xavier Fioramonti (NutriNeuro) \n\nResearch focus Group Kleinridders \nMy research interest aims at understanding causes and consequences of brain insulin resistance particularly with regard to understand the interaction of brain insulin sensitivity and mitochondrial function. We have shown that the consumption of HFD activates the innate immune system\, which is instrumental to induce hypothalamic leptin resistance with concomitant insulin resistance. Following\, we were able to reveal that type 2 diabetic patients exhibit reduced expression of mitochondrial chaperones in the hypothalamus. The resultant\, reduced mitochondrial stress response (MSR) induces brain insulin resistance identifying mitochondrial dysfunction as cause for hypothalamic insulin resistance. Recently\, we were able to show that the dysregulation of the MSR is one of the earliest alterations in obesity development and are caused by insulin resistance. Conversely\, treating neurons or mice with insulin\, increases the expression of MSR genes with protection against diet-induced weight gain. Thus\, the dysregulation of the MSR represents a cause and consequence of brain insulin resistance. \nWe further investigate consequences of brain insulin resistance with a particular focus on emotional behavior. Here we show that neuronal and glia specific deficiency of insulin receptor causes anxiety and depressive-like behavior due to alterations in the dopaminergic system. Currently we investigate mechanisms of acute intranasal insulin on emotional behavior in mice and men and identify acute alterations in the ventral striatum as potential target sites for insulin-induced improvements in emotional behavior. \n  \n
URL:https://www.bordeaux-neurocampus.fr/en/event/impromptu-seminar-andre-kleinridders/
CATEGORIES:For scientists,home-event,Impromptu seminar
ATTACH;FMTTYPE=image/jpeg:https://www.bordeaux-neurocampus.fr/wp-content/uploads/2020/01/Kleinridders-Dife_2019_4806.jpg
END:VEVENT
END:VCALENDAR