BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Bordeaux Neurocampus - ECPv4.9.10//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20190331T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20191027T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20191008T140000
DTEND;TZID=Europe/Paris:20191008T150000
DTSTAMP:20260413T193656
CREATED:20191001T134631Z
LAST-MODIFIED:20191001T140125Z
UID:111509-1570543200-1570546800@www.bordeaux-neurocampus.fr
SUMMARY:CBiB seminar - Laurent Bréhélin
DESCRIPTION:Séminaire de Bioinformatique et Biologie Computationnelle sur la thématique d’analyse de régulation transcriptionnelle par des méthodes statistiques. L’exposé sera suivi d’une pause café. \nLaurent Bréhélin\nLIRMM\, Univ. Montpellier\, CNRS \nProbing transcriptional regulation with statistical models \nLieu : Salle de Conférences du Centre de Génomique Fonctionnelle \nAbstract :\nGene expression in Eukaryotes is orchestrated by distinct regulatory mechanisms to ensure a wide variety of cell types and functions. While these regulations include actors as different as transcription factors (TFs)\, histone marks\, or chromatin structure\, the DNA sequence itself is invariably involved in the different processes. Hence\, a key challenge in regulatory genomics is to decipher the links between gene regulation and DNA sequence. In this talk\, I will present two attempts to this problem based on statistical machine learning and feature selection approaches. \nIn the first work [1]\, we probe sequence-level instructions for gene expression and develop a method to explain mRNA levels based solely on nucleotide features. Our method positions nucleotide composition as a critical component of gene expression. In the second one [2]\, we study TF combinations involved in the binding of a target TF in a particular cell type. We show that TF combinations are different between promoters and enhancers\, but similar for promoters of mRNAs\, lncRNAs and pri-miRNAs. \n[1] https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005921\n[2] https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-018-5408-0 \n
URL:https://www.bordeaux-neurocampus.fr/en/event/cbib-seminar-laurent-brehelin/
CATEGORIES:Other events
END:VEVENT
END:VCALENDAR