Vitamin A Deficiency Decreases the Expression of RARβ and RXRβ/γ in Adult Mouse Brain: Effect of RA Administration.

V. Enderlin, D. Higueret, S. Alfos, M. Husson, R. Jaffard, P. Higueret, V. Pallet
Nutritional Neuroscience. 2000-01-01; 3(3): 173-181
DOI: 10.1080/1028415x.2000.11747314

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1. Nutr Neurosci. 2000;3(3):173-81. doi: 10.1080/1028415X.2000.11747314.

Vitamin A Deficiency Decreases the Expression of RARβ and RXRβ/γ in Adult Mouse
Brain: Effect of RA Administration.

Enderlin V(1), Higueret D(2), Alfos S(1), Husson M(1), Jaffard R(3), Higueret
P(1), Pallet V(1).

Author information:
(1)a Laboratoire de Nutrition et Signalisation Cellulaire , ISTAB , Avenue des
Facultés , Université Bordeaux I , 33405 Talence, France.
(2)b Laboratoire de Biochimie , Hopital Pellegrin , 33076 Bordeaux , France.
(3)c Laboratoire de Neurosciences Cognitives (UMR CNRS 5807) , Université de
Bordeaux I , 33405 Talence, France.

Recent studies have revealed a novel and unexpected role of vitamin A, via its
nuclear receptors, in higher cognitive functions. We examined, in mouse brain,
the impact of vitamin A status on the level of retinoic acid nuclear receptor
(RAR and RXR) expression and on one of their responsive genes, that of the tissue
transglutaminase (tTG). Weanling male C57B1/6 mice fed a vitamin A deficient diet
developed a vitamin A deficiency which was characterized, after 26 weeks, by the
depletion of serum retinol, liver retinol and retinyl palmitate, and by the
decreased activity of liver tTG. After 27 weeks of the diet, the vitamin A
depleted mice exhibited a significantly lower amount of brain RAR β and RXR β/γ
mRNA relative to control mice. Vitamin A deficiency also resulted in a reduced
expression of tTG. When 35-week depleted mice were subsequently administrated RA
for 28 days, the expression of RA nuclear receptors and tTG was significantly
induced. The vitamin A deficiency mouse model and repletion provides a
physiological system for monitoring the effects of vitamin A status on gene
expression and on neurobiological processes in the adult brain.

DOI: 10.1080/1028415X.2000.11747314
PMID: 27414051

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