Transcriptome analysis of genes and gene networks involved in aggressive behavior in mouse and zebrafish
Am. J. Med. Genet.. 2016-04-19; 171(6): 827-838
DOI: 10.1002/ajmg.b.32451
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1. Am J Med Genet B Neuropsychiatr Genet. 2016 Sep;171(6):827-38. doi:
10.1002/ajmg.b.32451. Epub 2016 Apr 19.
Transcriptome analysis of genes and gene networks involved in aggressive behavior
in mouse and zebrafish.
Malki K(1), Du Rietz E(1), Crusio WE(2)(3), Pain O(4)(5), Paya-Cano J(1),
Karadaghi RL(1), Sluyter F(1), de Boer SF(6), Sandnabba K(7), Schalkwyk LC(8),
Asherson P(1), Tosto MG(1)(9).
Author information:
(1)King’s College London, Social, Genetic and Developmental Psychiatry Centre
(MRC), Institute of Psychiatry, Psychology and Neuroscience, United Kingdom.
(2)University of Bordeaux, Aquitaine Institute for Cognitive and Integrative
Neuroscience, Bordeaux, France.
(3)CNRS, Aquitaine Institute for Cognitive and Integrative Neuroscience,
Bordeaux, France.
(4)Centre of Brain and Cognitive Development, Birkbeck, University of London,
United Kingdom.
(5)Department of Non-Communicable Disease Epidemiology, London School of Hygiene
and Tropical Medicine, London, United Kingdom.
(6)Groningen Institute for Evolutionary LifeSciences (GELIFES), University of
Groningen, Groningen, The Netherlands.
(7)Faculty of Arts, Psychology and Theology, Åbo Akademi University, Turku,
Finland.
(8)School of Biological Sciences, University of Essex, Colchester, United
Kingdom.
(9)Laboratory for Cognitive Investigations and Behavioural Genetics, Tomsk State
University, Tomsk, Russia.
Despite moderate heritability estimates, the molecular architecture of aggressive
behavior remains poorly characterized. This study compared gene expression
profiles from a genetic mouse model of aggression with zebrafish, an animal model
traditionally used to study aggression. A meta-analytic, cross-species approach
was used to identify genomic variants associated with aggressive behavior. The
Rankprod algorithm was used to evaluated mRNA differences from prefrontal cortex
tissues of three sets of mouse lines (N = 18) selectively bred for low and high
aggressive behavior (SAL/LAL, TA/TNA, and NC900/NC100). The same approach was
used to evaluate mRNA differences in zebrafish (N = 12) exposed to aggressive or
non-aggressive social encounters. Results were compared to uncover genes
consistently implicated in aggression across both studies. Seventy-six genes were
differentially expressed (PFP