The stress hormone corticosterone conditions AMPAR surface trafficking and synaptic potentiation
Nat Neurosci. 2008-07-11; 11(8): 868-870
DOI: 10.1038/nn.2150
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1. Nat Neurosci. 2008 Aug;11(8):868-70. doi: 10.1038/nn.2150. Epub 2008 Jul 11.
The stress hormone corticosterone conditions AMPAR surface trafficking and
synaptic potentiation.
Groc L(1), Choquet D, Chaouloff F.
Author information:
(1)Physiologie Cellulaire de Synapse, UMR 5091 CNRS, Université Bordeaux 2,
Bordeaux 33077, France.
Corticosterone facilitates hippocampal glutamate transmission, but the cellular
pathways by which AMPA receptor (AMPAR) signaling is adjusted remain elusive.
Single quantum-dot imaging in live rat hippocampal neurons revealed that
corticosterone triggers, via distinct corticosteroid receptors, time-dependent
increases in GluR2-AMPAR surface mobility and synaptic surface GluR2 content.
Furthermore, corticosterone potentiates the increase of synaptic surface GluR2
contents by a chemical long-term potentiation stimulus, revealing the influence
that corticosterone has on AMPAR trafficking.
DOI: 10.1038/nn.2150
PMID: 18622402 [Indexed for MEDLINE]