SK2 channel expression and function in cerebellar Purkinje cells.
The Journal of Physiology. 2011-07-15; 589(14): 3433-3440
DOI: 10.1113/jphysiol.2011.205823
Read on PubMed
1. J Physiol. 2011 Jul 15;589(Pt 14):3433-40. doi: 10.1113/jphysiol.2011.205823.
Epub 2011 Apr 26.
SK2 channel expression and function in cerebellar Purkinje cells.
Hosy E(1), Piochon C, Teuling E, Rinaldo L, Hansel C.
Author information:
(1)Laboratoire Physiologie Cellulaire de la Synapse, CNRS, Bordeaux Neuroscience
Institute, University of Bordeaux, 33077 Bordeaux Cedex, France.
Small-conductance calcium-activated K(+) channels (SK channels) regulate the
excitability of neurons and their responsiveness to synaptic input patterns. SK
channels contribute to the afterhyperpolarization (AHP) following action
potential bursts, and curtail excitatory postsynaptic potentials (EPSPs) in
neuronal dendrites. Here we review evidence that SK2 channels are expressed in
rat cerebellar Purkinje cells during development and throughout adulthood, and
play a key role in diverse cellular processes such as the regulation of the spike
firing frequency and the modulation of calcium transients in dendritic spines. In
Purkinje cells as well as in other types of neurons, SK2 channel plasticity seems
to provide an important mechanism allowing these cells to adjust their intrinsic
excitability and to alter the probabilities for the induction of synaptic
learning correlates, such as long-term potentiation (LTP).
DOI: 10.1113/jphysiol.2011.205823
PMCID: PMC3167108
PMID: 21521760 [Indexed for MEDLINE]