Role of the supplementary motor area during reproduction of supra-second time intervals: An intracerebral EEG study
NeuroImage. 2019-05-01; 191: 403-420
DOI: 10.1016/j.neuroimage.2019.01.047
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Pfeuty M(1), Monfort V(2), Klein M(3), Krieg J(4), Collé S(3), Colnat-Coulbois
S(4), Brissart H(4), Maillard L(5).
Author information:
(1)University of Bordeaux, INCIA, UMR 5287, F-33000, Bordeaux, France.
(2)University of Lorraine, 2LPN, EA 7489, Rue du Général Delestraint, Metz,
F-57070, France. Electronic address: .
(3)University of Lorraine, 2LPN, EA 7489, Rue du Général Delestraint, Metz,
F-57070, France.
(4)Université de Lorraine, CRAN, UMR 7039, Campus Sciences, Boulevard des
Aiguillettes, 54500, Vandoeuvre-lès-Nancy, France; CNRS, CRAN, UMR 7039, Campus
Sciences, Boulevard des Aiguillettes, 54500, Vandoeuvre-lès-Nancy, France.
(5)Université de Lorraine, CRAN, UMR 7039, Campus Sciences, Boulevard des
Aiguillettes, 54500, Vandoeuvre-lès-Nancy, France; CNRS, CRAN, UMR 7039, Campus
Sciences, Boulevard des Aiguillettes, 54500, Vandoeuvre-lès-Nancy, France;
University Hospital of Nancy, Department of Neurology, 29 Avenue du
Maréchal-de-Lattre-de-Tassigny, Nancy, F-54035, France; Faculté de Médecine de
Nancy, Université de Lorraine, 9 Avenue de la Forêt de Haye, 54500,
Vandoeuvre-lès-Nancy, France.
The supplementary motor area (SMA) has been shown to be involved in interval
timing but its precise role remains a matter of debate. The present study was
aimed at examining, by means of intracerebral EEG recordings, the time course of
the activity in this structure, as well as in other functionally connected
cortical (frontal, cingulate, insular and temporal) areas, during a visual time
reproduction task. Four patients undergoing stereo-electroencephalography (SEEG)
for presurgical investigation of refractory focal epilepsy were enrolled. They
were selected on the presence of depth electrodes implanted within the SMA. They
were instructed to encode, keep in memory and then reproduce the duration (3, 5
and 7 s) of emotionally-neutral or negative pictures. Emotional stimuli were
used with the aim of examining neural correlates of temporal distortions induced
by emotion. Event-related potentials (ERPs) were analyzed during three periods:
During and at the extinction of the target interval (TI) and at the beginning of
the reproduction interval (RI). Electrophysiological data revealed an ERP
time-locked to TI-offset whose amplitude varied monotonically with TI-duration.
This effect was observed in three out of the four patients, especially within
the SMA and the insula. It also involved the middle and anterior cingulate
cortex, the superior, middle and inferior frontal gyri and the paracentral
lobule. These effects were modulated by the prior TI-duration and predicted
variations in temporal reproduction accuracy. In contrast, modulations of ERPs
with TI-duration, emotion or temporal performance during the target or the
reproduction interval were modest and less consistent across patients. These
results demonstrate that, during reproduction of supra-second time intervals,
the SMA, in concert with a fronto-insular network, is involved at the end of the
target interval, and suggest a role in the duration categorization and decision
making operations or alternatively in the preparedness of the timing of the
future movement that will be executed during the reproduction phase.
Copyright © 2019 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.neuroimage.2019.01.047
PMID: 30708103 [Indexed for MEDLINE]