Real-time nanoscale organization of amyloid precursor protein

Shekhar Kedia, Pratyush Ramakrishna, Pallavi Rao Netrakanti, Mini Jose, Jean-Baptiste Sibarita, Suhita Nadkarni, Deepak Nair
Nanoscale. 2020-01-01; 12(15): 8200-8215
DOI: 10.1039/d0nr00052c


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Regulatory nanodomains modulated by lateral diffusion control transient equilibrium between pools of APP within an excitatory synapse. Molecular fingerprints of these nanodomains are altered in variants of APP implicated in Alzheimer’s Disease.

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