Power Fluctuations in Beta and Gamma Frequencies in Rat Globus Pallidus: Association with Specific Phases of Slow Oscillations and Differential Modulation by Dopamine D-1 and D-2 Receptors
Journal of Neuroscience. 2011-04-20; 31(16): 6098-6107
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1. J Neurosci. 2011 Apr 20;31(16):6098-107. doi: 10.1523/JNEUROSCI.3311-09.2011.
Power fluctuations in beta and gamma frequencies in rat globus pallidus:
association with specific phases of slow oscillations and differential modulation
by dopamine D1 and D2 receptors.
Dejean C(1), Arbuthnott G, Wickens JR, Le Moine C, Boraud T, Hyland BI.
(1)Department of Anatomy and Structural Biology, School of Medical Sciences,
University of Otago, Dunedin 9054, New Zealand.
Modulation of oscillatory activity through basal ganglia-cortical loops in
specific frequency bands is thought to reflect specific functional states of
neural networks. A specific negative correlation between beta and gamma sub-bands
has been demonstrated in human basal ganglia and may be key for normal basal
ganglia function. However, these studies were limited to Parkinson’s disease
patients. To confirm that this interaction is a feature of normal basal ganglia,
we recorded local field potential (LFP) from electrodes in globus pallidus (GP)
of intact rats. We found significant negative correlation between specific
frequencies within gamma (≈ 60 Hz) and beta (≈ 14 Hz) bands. Furthermore, we show
that fluctuations in power at these frequencies are differentially nested within
slow (≈ 3 Hz) oscillations in the delta band, showing maximum power at distinct
and different phases of delta. These results suggest a hierarchical organization
of LFP frequencies in the rat GP, in which a low-frequency signal in the basal
ganglia can predict the timing and interaction of power fluctuations across
higher frequencies. Finally, we found that dopamine D(1) and D(2) receptor
antagonists differentially affected power in gamma and beta bands and also had
different effects on correlation between them and the nesting within delta,
indicating an important role for endogenous dopamine acting on direct and
indirect pathway neurons in the maintenance of the hierarchical organization of
frequency bands. Disruption of this hierarchical organization and subsequent
disordered beta-gamma balance in basal ganglia disorders such as Parkinson’s
disease may be important in the pathogenesis of their symptoms.
PMID: 21508235 [Indexed for MEDLINE]