PCC characteristics at rest in 10-year memory decliners.

Charlotte Bernard, Bixente Dilharreguy, Catherine Helmer, Sandra Chanraud, Hélène Amieva, Jean-François Dartigues, Michèle Allard, Gwénaëlle Catheline
Neurobiology of Aging. 2015-10-01; 36(10): 2812-2820
DOI: 10.1016/j.neurobiolaging.2015.07.002

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1. Neurobiol Aging. 2015 Oct;36(10):2812-20. doi:
10.1016/j.neurobiolaging.2015.07.002. Epub 2015 Jul 9.

PCC characteristics at rest in 10-year memory decliners.

Bernard C(1), Dilharreguy B(2), Helmer C(3), Chanraud S(4), Amieva H(5),
Dartigues JF(6), Allard M(4), Catheline G(4).

Author information:
(1)Institut de Neurosciences Cognitives et Intégratives d’Aquitaine (INCIA),
University of Bordeaux, UMR 5287, Talence, France; Centre National de la
Recherche Scientifique (CNRS), INCIA, UMR 5287, Talence, France; Ecole Pratique
des Hautes Etudes (EPHE), Bordeaux, France. Electronic address:
.
(2)Institut de Neurosciences Cognitives et Intégratives d’Aquitaine (INCIA),
University of Bordeaux, UMR 5287, Talence, France; Centre National de la
Recherche Scientifique (CNRS), INCIA, UMR 5287, Talence, France.
(3)Institut National de la Santé et de la Recherche Médicale (INSERM), Institut
de Santé Publique, d’Epidémiologie et de Développement (ISPED), Centre INSERM
U897-Epidemiologie-Biostatistique, Bordeaux, France; University of Bordeaux,
Bordeaux, France; INSERM, Clinical Investigation Center-Clinical Epidemiology 7,
Bordeaux, France.
(4)Institut de Neurosciences Cognitives et Intégratives d’Aquitaine (INCIA),
University of Bordeaux, UMR 5287, Talence, France; Centre National de la
Recherche Scientifique (CNRS), INCIA, UMR 5287, Talence, France; Ecole Pratique
des Hautes Etudes (EPHE), Bordeaux, France.
(5)Institut National de la Santé et de la Recherche Médicale (INSERM), Institut
de Santé Publique, d’Epidémiologie et de Développement (ISPED), Centre INSERM
U897-Epidemiologie-Biostatistique, Bordeaux, France; University of Bordeaux,
Bordeaux, France.
(6)Institut National de la Santé et de la Recherche Médicale (INSERM), Institut
de Santé Publique, d’Epidémiologie et de Développement (ISPED), Centre INSERM
U897-Epidemiologie-Biostatistique, Bordeaux, France; University of Bordeaux,
Bordeaux, France; Memory Consultation, University Hospital, Centre Mémoire de
Ressources et de Recherche (CMRR), Bordeaux, France.

The present research sought to characterize the intrinsic functional networks
associated with a 10-year episodic memory decline in elderly using data from a
longitudinal population-based cohort (Bordeaux-3City). Complementary measures of
whole-brain resting-state functional magnetic resonance imaging investigations
were combined to compare functional architecture of brain networks both at
connectional and topological levels in 22 decliners to 22 nondecliners; episodic
memory decline being assessed through a multiple time point Free and Cued
Selective Reminding Test. The decliners presented differences in functional
architecture centered on the posterior cingulate cortex, characterized by a
significant decrease of connectivity intensity, a significant increased
centrality. In accordance, a decrease of the functional connectivity inside the
default mode network was observed in the decliners. Our results highlight the
central role of the posterior cingulate cortex in a slow but reliable memory
decline in elderly. Because functional alterations of this region are currently
described in Alzheimer’s disease, this functional signature could constitute a
risk for Alzheimer’s disease.

Copyright © 2015 Elsevier Inc. All rights reserved.

DOI: 10.1016/j.neurobiolaging.2015.07.002
PMID: 26234756 [Indexed for MEDLINE]

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