Organization and dynamics of the actin cytoskeleton during dendritic spine morphological remodeling.
Cell. Mol. Life Sci.. 2016-04-22; 73(16): 3053-3073
DOI: 10.1007/s00018-016-2214-1
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1. Cell Mol Life Sci. 2016 Aug;73(16):3053-73. doi: 10.1007/s00018-016-2214-1. Epub
2016 Apr 22.
Organization and dynamics of the actin cytoskeleton during dendritic spine
morphological remodeling.
Chazeau A(1)(2)(3), Giannone G(4)(5).
Author information:
(1)Interdisciplinary Institute for Neuroscience, University of Bordeaux, UMR
5297, 33000, Bordeaux, France.
(2)Interdisciplinary Institute for Neuroscience, CNRS, UMR 5297, 33000, Bordeaux,
France.
(3)Cell Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH,
Utrecht, The Netherlands.
(4)Interdisciplinary Institute for Neuroscience, University of Bordeaux, UMR
5297, 33000, Bordeaux, France. .
(5)Interdisciplinary Institute for Neuroscience, CNRS, UMR 5297, 33000, Bordeaux,
France. .
In the central nervous system, most excitatory post-synapses are small
subcellular structures called dendritic spines. Their structure and morphological
remodeling are tightly coupled to changes in synaptic transmission. The F-actin
cytoskeleton is the main driving force of dendritic spine remodeling and sustains
synaptic plasticity. It is therefore essential to understand how changes in
synaptic transmission can regulate the organization and dynamics of actin binding
proteins (ABPs). In this review, we will provide a detailed description of the
organization and dynamics of F-actin and ABPs in dendritic spines and will
discuss the current models explaining how the actin cytoskeleton sustains both
structural and functional synaptic plasticity.
DOI: 10.1007/s00018-016-2214-1
PMID: 27105623 [Indexed for MEDLINE]