Omics analysis of mouse brain models of human diseases.

Véronique Paban, Béatrice Loriod, Claude Villard, Luc Buee, David Blum, Susanna Pietropaolo, Yoon H. Cho, Sylvie Gory-Faure, Elodie Mansour, Ali Gharbi, Béatrice Alescio-Lautier
Gene. 2017-02-01; 600: 90-100
DOI: 10.1016/j.gene.2016.11.022

PubMed
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Paban V(1), Loriod B(2), Villard C(3), Buee L(4), Blum D(4), Pietropaolo S(5), Cho YH(5), Gory-Faure S(6), Mansour E(7), Gharbi A(7), Alescio-Lautier B(7).

Author information:
(1)Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France. Electronic address:
.
(2)Aix Marseille Univ, INSERM UMR 1090, TAGC, Marseille, France.
(3)Aix Marseille Univ, INSERM, CRO2 UMR S911, Faculté de pharmacie, Marseille,
France.
(4)Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille,
France.
(5)INCIA, Université de Bordeaux, Pessac, France; INCIA, UMR 5287, CNRS, Pessac,
France.
(6)INSERM, U1216, Grenoble, France; Univ. Grenoble Alpes, Grenoble Institut
Neurosciences, Grenoble, France; CEA, BIG, Grenoble, France.
(7)Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.

The identification of common gene/protein profiles related to brain alterations,
if they exist, may indicate the convergence of the pathogenic mechanisms driving
brain disorders. Six genetically engineered mouse lines modelling
neurodegenerative diseases and neuropsychiatric disorders were considered. Omics
approaches, including transcriptomic and proteomic methods, were used. The
gene/protein lists were used for inter-disease comparisons and further
functional and network investigations. When the inter-disease comparison was
performed using the gene symbol identifiers, the number of genes/proteins
involved in multiple diseases decreased rapidly. Thus, no genes/proteins were
shared by all 6 mouse models. Only one gene/protein (Gfap) was shared among 4
disorders, providing strong evidence that a common molecular signature does not
exist among brain diseases. The inter-disease comparison of functional processes
showed the involvement of a few major biological processes indicating that brain
diseases of diverse aetiologies might utilize common biological pathways in the
nervous system, without necessarily involving similar molecules.

Copyright © 2016 Elsevier B.V. All rights reserved.

 

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