OFSEP, a nationwide cohort of people with multiple sclerosis: Consensus minimal MRI protocol.

F. Cotton, S. Kremer, S. Hannoun, S. Vukusic, V. Dousset
Journal of Neuroradiology. 2015-06-01; 42(3): 133-140
DOI: 10.1016/j.neurad.2014.12.001

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1. J Neuroradiol. 2015 Jun;42(3):133-40. doi: 10.1016/j.neurad.2014.12.001. Epub
2015 Feb 7.

OFSEP, a nationwide cohort of people with multiple sclerosis: Consensus minimal
MRI protocol.

Cotton F(1), Kremer S(2), Hannoun S(3), Vukusic S(4), Dousset V(5); Imaging
Working Group of the Observatoire Français de la Sclérose en Plaques.

Collaborators: Amélie R, Armspach JP, Audoin B, Barillot C, Berry I, Bonneville
F, Boutet C, Castelnovo G, Cervenanski F, Cohen M, Commowick O, Cotton F, De Seze
J, Dousset V, Durand-dubief F, Edan G, Ferre JC, Galanaud D, Glattard T, Grand S,
Guillaumont J, Guillevin R, Guttmann C, Hannoun S, Heitz F, Krainik A, Kremer S,
Labauge P, Menjot de Champfleur N, Ranjeva JP, Roch JA, Sappey-Marinier D,
Savatovsky J, Stankoff B, Tourbah A, Tourdias T, Vukusic S.

Author information:
(1)Service de radiologie, hospices civils de Lyon, centre hospitalier Lyon Sud,
Pierre-Bénite, France; Inserm U1044, université de Lyon, université Lyon 1,
CREATIS, CNRS UMR 5220, Villeurbanne, France. Electronic address:
.
(2)Service d’imagerie 2, FMTS, université de Strasbourg, hôpital de Hautepierre,
ICube UMR 7357, CHU de Strasbourg, Strasbourg, France.
(3)Inserm U1044, université de Lyon, université Lyon 1, CREATIS, CNRS UMR 5220,
Villeurbanne, France.
(4)Service de neurologie A et fondation Eugène-Devic EDMUS pour la sclérose en
plaques, hôpital neurologique, hospices civils de Lyon, Bron, France.
(5)Institut de bio-imagerie de Bordeaux UMS 3428, University of Bordeaux,
Bordeaux, France; Inserm, U862, physiopathologie de la plasticité neuronale,
Bordeaux, France; Service de neuroimagerie diagnostique de thérapeutique, CHU de
Bordeaux, Bordeaux, France.

Multiple sclerosis (MS) is most generally considered as a severe disease with
high physical and mental risks of disability. Since the end of the 1990s, several
high cost long-term disease-modifying treatments provided some clinical
efficiency. However, patient’s follow-up was needed for the detection and the
assessment of their side-effects. The “Observatoire français de la sclérose en
plaques” (OFSEP) project aims to improve the clinical, biological and imaging
systematic longitudinal follow-up of patients. It should increase the quality,
efficiency and safety of patients’ care, with a unique opportunity of large
scale, about 41,000 patients followed in 62 French centers using the European
Database for Multiple Sclerosis (EDMUS) software. OFSEP is divided into three
working groups (clinical, biological and imaging). The imaging working group
defines standards for routine MRI follow-up in the whole cohort and contains
three subgroups: acquisition, workflow, and data processing. A common and
feasible brain and spinal cord acquisition protocol has been defined by the
acquisition group, and accepted by the OFSEP steering and scientific committees.
This protocol can be implemented in all French MRI centers. The major MRI
manufacturers have agreed to provide the dedicated collection of sequences as an
“OFSEP box” with every software upgrade or new MRI machine. The new OFSEP
protocol will provide a unique opportunity to study a population-based collection
of data from people with MS.

Copyright © 2015 Elsevier Masson SAS. All rights reserved.

DOI: 10.1016/j.neurad.2014.12.001
PMID: 25660217 [Indexed for MEDLINE]

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