Melatonin is able to influence its secretion in humans: Description of a phase-response curve
Neuroendocrinology. 1994-01-01; 60(1): 105-112
DOI: 10.1159/000126726
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1. Neuroendocrinology. 1994 Jul;60(1):105-12.
Melatonin is able to influence its secretion in humans: description of a
phase-response curve.
Zaidan R(1), Geoffriau M, Brun J, Taillard J, Bureau C, Chazot G, Claustrat B.
Author information:
(1)Service de Neurologie, Hôpital Neurologique, Lyon, France.
A single physiological dose of melatonin (20 micrograms for 3 h given
intravenously at different times of the day (04.00-12.00, 16.00 and 20.00 h) was
able to shift the endogenous plasma melatonin profile of healthy volunteers under
entrained conditions according to a phase-response curve (PRC). ANOVA showed an
effect of the time of administration on the onset, the acrophase or the offset of
the melatonin profiles. These profiles were significantly delayed when the
infusion was administered at 12.00 h and advanced when the infusion was given at
20.00 h. Further, the AUCs evaluated on the nocturnal melatonin profiles were
increased after the 04.00 h infusion (+20.5%, p < 0.05), whereas they were
decreased after the 12.00 h infusion (-20%, p < 0.05). Lastly, no alteration was
observed for cortisol rhythm, whatever the time of melatonin administration.
These results, which show that according to a PRC the system regulating melatonin
secretion is sensitive to a single short-term administration of the hormone given
at a low dose, support the paradigm of the endogenous synchronizer melatonin.
DOI: 10.1159/000126726
PMID: 8090277 [Indexed for MEDLINE]