L-DOPA-induced dyskinesias, motor fluctuations and health-related quality of life: the COPARK survey.
Eur J Neurol. 2017-10-09; 24(12): 1532-1538
DOI: 10.1111/ene.13466
Read on PubMed
1. Eur J Neurol. 2017 Dec;24(12):1532-1538. doi: 10.1111/ene.13466. Epub 2017 Oct 9.
L-DOPA-induced dyskinesias, motor fluctuations and health-related quality of
life: the COPARK survey.
Perez-Lloret S(1)(2), Negre-Pages L(3)(4), Damier P(5), Delval A(6), Derkinderen
P(5), Destée A(6), Meissner WG(7), Tison F(7), Rascol O(1); of the COPARK Study
Group.
Collaborators: Spampinato U, Damier P, Derkinderen P, Rascol O, Rey-Zermati V,
Soulages X, Azais-Vuillemin C, Stambouli N, Rouane R, Salandini M, Boulesteix M,
Barreda M, Castan D, Ojero-Senard A, Angibaud G, Balague P, Danielli A, Attane N,
Faucheux M, Henry P, Rougie H, Jardillier B, Azais F, Damase L, Destee A, Lejeune
P, Delabrousse-Mayoux M, Bonenfant S, Darmanaden R, Robinson A, Gaujard E,
Puymirat E, Goumard E, Godin H, Latxague C, Deligny C, Lebouvier T,
Lanctin-Garcia C, Roy M, Verbist-Talmant V, Bertout P.
Author information:
(1)INSERM, Services de Pharmacologie Clinique et Neurosciences, Centre
d’Investigation Clinique CIC 1436, NS-Park/FCRIN Network, NeuroToul COEN Center,
Université de Toulouse UPS, CHU de Toulouse, Toulouse, France.
(2)Institute of Cardiology Research, University of Buenos Aires, National
Research Council (CONICET-ININCA), Buenos Aires, Argentina.
(3)LN Pharma, Toulouse.
(4)Département d’Information Médicale, Unité de Recherche Clinique et
Epidémiologie, Hôpital la Colombière, Montpellier.
(5)Department of Neurology, INSERM, NS-Park/FCRIN Network, Université de Nantes,
CHU de Nantes, Nantes.
(6)Department of Neurology, INSERM, NS-Park/FCRIN Network, Université de Lille,
CHU de Lille, U 837 Eq6, Lille.
(7)CNRS, CHU de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293,
Service de Neurologie, NS-Park/FCRIN Network, Université de Bordeaux, Bordeaux,
France.
BACKGROUND AND PURPOSE: Studies assessing the correlations between L-DOPA-induced
dyskinesias (LIDs) and motor fluctuations with health-related quality of life
(HRQoL) in Parkinson’s disease (PD) have yielded conflicting results. This study
aimed to assess the relationship between LIDs and motor fluctuations with HRQoL
in patients with PD, and to assess the relative contribution of their severity
and duration in a large sample of patients with PD.
METHODS: A total of 683 patients with PD from the COPARK survey were evaluated.
HRQoL was assessed using the 39-Item Parkinson’s Disease Questionnaire (PDQ-39)
(primary outcome) and 36-Item Short Form Survey (SF-36). The daily duration and
severity of LIDs were obtained from Unified Parkinson’s Disease Rating Scale
(UPDRS) IV items 32 and 33, respectively. The daily duration of motor
fluctuations was obtained from UPDRS IV item 36 and severity was estimated as the
difference between the UPDRS 2 (Activities of Daily Living) score in ‘OFF’ versus
‘ON’ condition.
RESULTS: A total of 235 patients with PD (35%) experienced motor fluctuations and
182 (27%) experienced LIDs. The PDQ-39 total and SF-36 physical scores were
significantly worse in patients with LIDs, after adjusting for the presence of
motor fluctuations. The PDQ-39 total score and SF-36 physical and mental score
were significantly worse in patients with motor fluctuations, after adjusting for
the presence of LIDs. The severity of LIDs and the duration of motor fluctuations
significantly and independently affected PDQ-39 scores. The SF-36 physical score
was affected only by the severity of motor fluctuations, whereas the mental score
was not affected by any of the aforementioned variables.
CONCLUSION: Our findings suggest that LIDs (mainly their severity) and motor
fluctuations (mainly their duration) correlate independently with HRQoL in
patients with PD.
© 2017 EAN.
DOI: 10.1111/ene.13466
PMID: 28940893 [Indexed for MEDLINE]