Impact of Lactobacillus fermentum and dairy lipids in the maternal diet on the fatty acid composition of pups’ brain and peripheral tissues

C. Joffre, A.L. Dinel, A. Aubert, C. Fressange-Mazda, P. Le Ruyet, S. Layé
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-12-01; 115: 24-34
DOI: 10.1016/j.plefa.2016.10.002

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1. Prostaglandins Leukot Essent Fatty Acids. 2016 Dec;115:24-34. doi:
10.1016/j.plefa.2016.10.002. Epub 2016 Oct 11.

Impact of Lactobacillus fermentum and dairy lipids in the maternal diet on the
fatty acid composition of pups’ brain and peripheral tissues.

Joffre C(1), Dinel AL(2), Aubert A(3), Fressange-Mazda C(4), Le Ruyet P(5), Layé
S(3).

Author information:
(1)INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, 33076 Bordeaux, France;
Univ. Bordeaux, Nutrition et Neurobiologie Intégrée, UMR 1286, 33076 Bordeaux,
France. Electronic address: .
(2)INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, 33076 Bordeaux, France;
Univ. Bordeaux, Nutrition et Neurobiologie Intégrée, UMR 1286, 33076 Bordeaux,
France; Nutribrain Research and Technology transfer of Nutrition et Neurobiologie
Intégrée, 33076 Bordeaux, France.
(3)INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, 33076 Bordeaux, France;
Univ. Bordeaux, Nutrition et Neurobiologie Intégrée, UMR 1286, 33076 Bordeaux,
France.
(4)Lactalis Nutrition Europe, Torce, France.
(5)Lactalis Recherche et Développement, Retiers, France.

The aim of the study was to determine the effect of maternal diets administered
since day 1 of gestation and containing dairy lipids or vegetable oils differing
in the supply of n-3 polyunsaturated fatty acids (n-3 PUFAs) (equilibrated or
deficient) and of Lactobacillus fermentum (L. fermentum) on the docosahexaenoic
acid (DHA) accretion in the pups at postnatal day 14 in the prefrontal cortex
(PFC) and hippocampus (HC) for brain structures and in the liver and adipose
tissue for peripheral tissues. Maternal milk fatty acid composition was also
assessed by analyzing the fatty acid composition of the gastric content of the
pups. DHA was higher in mice supplemented with L. fermentum than in mice in the
deficient group in HC and PFC and also in liver and adipose tissue. This increase
could be linked to the slight but significant increase in C18:3n-3 in the
maternal milk. This proportion was comparable in the dairy lipid group for which
the brain DHA level was the highest. L. fermentum may have a key role in the
protection of the brain during the perinatal period via the neuronal accretion of
n-3 PUFAs, especially during n-3 PUFA deficiency.

Copyright © 2016 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.plefa.2016.10.002
PMID: 27914510 [Indexed for MEDLINE]

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