Genetic analysis of the relationships between behavioral and neuroendocrine traits in Roman High and Low Avoidance rat lines
Behav Genet. 1995-07-01; 25(4): 371-384
DOI: 10.1007/bf02197288
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1. Behav Genet. 1995 Jul;25(4):371-84.
Genetic analysis of the relationships between behavioral and neuroendocrine
traits in Roman High and Low Avoidance rat lines.
Castanon N(1), Perez-Diaz F, Mormède P.
Author information:
(1)Laboratoire de Génétique du Stress et Neurobiologie de l’Adaptation, CJF
INSERM 94-05-INRA, Université de Bordeaux II, France.
In order to determine whether the coselection observed between the selection
trait (active avoidance behavior) of the Roman High Avoidance (RHA) and Roman Low
Avoidance (RLA) rat lines and their neuroendocrine characteristics were
genetically determined, we analyzed, in nonsegregating (RHA, RLA, and F1) and
segregating (F2 and the two backcrosses) crosses, the inheritance pattern and the
phenotypic correlations among behavioral (shuttle-box behavior), physiological
(body, adrenal, and thymus weights), and neuroendocrine (corticosterone and
prolactin reactivity, catecholamine enzyme activities) variables. Physiological
characteristics and enzyme activities have a crucial role in sex dissociation.
Avoidance behavior and prolactin reactivity to novel environment remained
associated in segregating crosses despite gene rearrangement. They represented
the most important variables to differentiate the Roman lines, perhaps sharing a
common regulatory mechanism under genetic control.
DOI: 10.1007/BF02197288
PMID: 7575368 [Indexed for MEDLINE]