Galanin-R1 receptor mRNA expression in the hypothalamus of the Brattelboro rat

Marc Landry, Katarina Åman, Arlette Burlet, Tomas Hökfelt
NeuroReport. 1999-09-01; 10(13): 2823-2827
DOI: 10.1097/00001756-199909090-00023

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1. Neuroreport. 1999 Sep 9;10(13):2823-7.

Galanin-R1 receptor mRNA expression in the hypothalamus of the Brattelboro rat.

Landry M(1), Aman K, Burlet A, Hökfelt T.

Author information:
(1)Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Using in situ hybridization the regulation of mRNA encoding the galanin receptor
R1 was investigated in the mutant Brattelboro (diabetes insipidus) rat. We here
report an increase of the galanin receptor R1 mRNA levels in the hypothalamic
supraoptic and paraventricular nuclei of the mutant strains. The increase seemed
to be confined to magnocellular neurons, since no changes were detected in
galanin receptor R1 mRNA levels in the extra-hypothalamic nucleus of the
olfactory tract. The results confirm that osmotic stimulation induces
up-regulation of galanin receptor R1 mRNA levels. This may increase the
sensitivity to galanin peptide, the endogenous ligand for this receptor.

DOI: 10.1097/00001756-199909090-00023
PMID: 10511447 [Indexed for MEDLINE]

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