Gait Change Is Associated with Cognitive Outcome after an Acute Ischemic Stroke.
Front. Aging Neurosci.. 2017-05-18; 9:
DOI: 10.3389/fnagi.2017.00153
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1. Front Aging Neurosci. 2017 May 18;9:153. doi: 10.3389/fnagi.2017.00153.
eCollection 2017.
Gait Change Is Associated with Cognitive Outcome after an Acute Ischemic Stroke.
Sagnier S(1)(2), Renou P(3), Olindo S(3), Debruxelles S(3), Poli M(3), Rouanet
F(3), Munsch F(4), Tourdias T(4)(5), Sibon I(2)(3).
Author information:
(1)CHU Pasteur 2, Unité Neuro-VasculaireNice, France.
(2)UMR 5287 Centre National de la Recherche Scientifique, Université de Bordeaux,
EPHE PSL Research UniversityBordeaux, France.
(3)CHU de Bordeaux, Unité Neuro-VasculaireBordeaux, France.
(4)CHU de Bordeaux, Neuroradiologie Diagnostique et ThérapeutiqueBordeaux,
France.
(5)Health and Human Sciences Department, Université de BordeauxBordeaux, France.
Background: Cognition and gait have often been studied separately after stroke
whereas it has been suggested that these two domains could interact through a
cognitive-motor interference. Objective: To evaluate the influence of gait
changes on cognitive outcome after an ischemic stroke (IS). Methods: We conducted
a prospective and monocentric study including patients admitted for an acute
supratentorial IS with a National Institute of Health Stroke Score ≤ 15.
Cognition, gait and motor disability were evaluated at baseline, 3 months and 1
year post-stroke, using the Montreal Cognitive Assessment (MoCA), the 10-m
walking test (10-MWT) and the Fugl-Meyer motor assessment (FMMA). The effect of
changes in 10-MWT over the year of follow-up on MoCA changes was estimated using
a generalized linear mixed model with FMMA, age and gender as covariates.
Results: Two hundred and Twelve patients were included (71% male, age 64 ± 13
years old). 10-MWT improved from baseline to 1 year (p < 0.001), as did MoCA (p <
0.001) and FMMA (p < 0.001) scores. Ninety-nine patients (47%) had a MoCA