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	<title>Scientific articles &#8211; Bordeaux Neurocampus</title>
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	<description>Département de neurosciences de l&#039;université de Bordeaux</description>
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	<title>Scientific articles &#8211; Bordeaux Neurocampus</title>
	<link>https://www.bordeaux-neurocampus.fr/en/</link>
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		<title>Mental health and substance use in Europe: initial steps towards a common European approach</title>
		<link>https://www.bordeaux-neurocampus.fr/en/article/mental-health-and-substance-use-in-europe-initial-steps-towards-a-common-european-approach/</link>
		
		<dc:creator><![CDATA[Arnaud Rodriguez]]></dc:creator>
		<pubDate>Tue, 22 Sep 2026 00:00:00 +0000</pubDate>
				<guid isPermaLink="false">https://www.bordeaux-neurocampus.fr/?post_type=article&#038;p=206537</guid>

					<description><![CDATA[Abstract Background and aims: Comorbid substance use and other mental health disorders contribute to more than one million years lived with disability in Europe according to the Global Burden of Disease study. They require a comprehensive approach, yet, in Europe, there is considerable variability in the treatment of these patients. The European Union Drugs Agency (EUDA) is committed to address comorbidity in Europe by providing evidence of epidemiological situation and approaches to interventions and supporting a common European approach. Methods: The methods used to support the promotion of a European approach to comorbidity were the following: a) setting up an&#8230;]]></description>
		
		
		
			</item>
		<item>
		<title>Generalizable and equitable automated ischaemic stroke lesion segmentation with vision transformers</title>
		<link>https://www.bordeaux-neurocampus.fr/en/article/generalizable-and-equitable-automated-ischaemic-stroke-lesion-segmentation-with-vision-transformers/</link>
		
		<dc:creator><![CDATA[Arnaud Rodriguez]]></dc:creator>
		<pubDate>Thu, 17 Sep 2026 00:00:00 +0000</pubDate>
				<guid isPermaLink="false">https://www.bordeaux-neurocampus.fr/?post_type=article&#038;p=206491</guid>

					<description><![CDATA[Abstract Background Ischaemic stroke, a leading cause of death and disability, relies on neuroimaging for characterising the anatomical pattern of injury. Diffusion-weighted MRI (DWI) provides the most anatomically specific signal in acute ischaemic stroke but poses substantial challenges for automated lesion segmentation due to susceptibility artefacts, lesion morphological heterogeneity, comorbid pathology, instrumental variability, and limited labelled data. Current U-Net-based models therefore underperform, a problem accentuated by evaluation metrics that neglect anatomical, subpopulation and acquisition-dependent variability. Methods We train 3D vision transformer–based segmentation models on a multi-site DWI dataset comprising 3563 annotated lesion-positive and 6900 lesion-negative volumes, using balanced cross-validation splits.&#8230;]]></description>
		
		
		
			</item>
		<item>
		<title>A Predictive Coding Model for Memory Replay in the Neocortex</title>
		<link>https://www.bordeaux-neurocampus.fr/en/article/a-predictive-coding-model-for-memory-replay-in-the-neocortex/</link>
		
		<dc:creator><![CDATA[Arnaud Rodriguez]]></dc:creator>
		<pubDate>Tue, 15 Sep 2026 00:00:00 +0000</pubDate>
				<guid isPermaLink="false">https://www.bordeaux-neurocampus.fr/?post_type=article&#038;p=206175</guid>

					<description><![CDATA[]]></description>
		
		
		
			</item>
		<item>
		<title>High-Resolution Disconnectome Predicts Outcome and Response to Thrombectomy in Basilar Artery Occlusion</title>
		<link>https://www.bordeaux-neurocampus.fr/en/article/high-resolution-disconnectome-predicts-outcome-and-response-to-thrombectomy-in-basilar-artery-occlusion/</link>
		
		<dc:creator><![CDATA[Arnaud Rodriguez]]></dc:creator>
		<pubDate>Fri, 11 Sep 2026 00:00:00 +0000</pubDate>
				<guid isPermaLink="false">https://www.bordeaux-neurocampus.fr/?post_type=article&#038;p=206123</guid>

					<description><![CDATA[BACKGROUND: Acute basilar artery occlusion causes devastating strokes. Despite the benefit of endovascular treatment, the optimal management remains controversial in specific subgroups, particularly patients with mild deficits, and would benefit from robust prognostic tools. Given the dense white matter networks within the posterior fossa, we tested whether quantifying disconnections from acute diffusion-weighted imaging could improve outcome prediction and identify responders to recanalization compared with conventional metrics. METHODS: We conducted a secondary analysis of a prospective multicenter stroke registry in France, including consecutive patients (2017–2024) with basilar artery occlusion and admission magnetic resonance imaging. Ultra-high-resolution diffusion magnetic resonance imaging was acquired&#8230;]]></description>
		
		
		
			</item>
		<item>
		<title>Dendritic shaft constrictions shape synaptic integration in neurons</title>
		<link>https://www.bordeaux-neurocampus.fr/en/article/dendritic-shaft-constrictions-shape-synaptic-integration-in-neurons/</link>
		
		<dc:creator><![CDATA[Arnaud Rodriguez]]></dc:creator>
		<pubDate>Fri, 11 Sep 2026 00:00:00 +0000</pubDate>
				<guid isPermaLink="false">https://www.bordeaux-neurocampus.fr/?post_type=article&#038;p=206146</guid>

					<description><![CDATA[For nearly 150 years, textbooks have described dendritic morphology as optimized for efficient synaptic voltage transfer from spines to the soma, implemented as a tubular design respecting Rall’s 3/2 rule for impedance matching at branch points. Here, we reveal that this view is an oversimplification. Using multiple high-resolution imaging techniques, we demonstrate that dendrites in cortical and hippocampal neurons exhibit nanoscale constrictions, termed dendritic shaft constrictions (DSCs), with diameters ranging from ∼100 to 500 nanometers in mice. We also identified DSCs in human hippocampal and cortical neurons. We provide theoretical and experimental lines of evidence that these constrictions effectively partition the&#8230;]]></description>
		
		
		
			</item>
		<item>
		<title>Retinal Microvascular Correlates of Cerebral Small Vessel Disease in Older Age</title>
		<link>https://www.bordeaux-neurocampus.fr/en/article/retinal-microvascular-correlates-of-cerebral-small-vessel-disease-in-older-age/</link>
		
		<dc:creator><![CDATA[Arnaud Rodriguez]]></dc:creator>
		<pubDate>Tue, 08 Sep 2026 00:00:00 +0000</pubDate>
				<guid isPermaLink="false">https://www.bordeaux-neurocampus.fr/?post_type=article&#038;p=205309</guid>

					<description><![CDATA[1. Neurology. 2026 Sep 8;107(5):e214551. doi: 10.1212/WNL.0000000000214551. Epub 2026 Aug 12. Retinal Microvascular Correlates of Cerebral Small Vessel Disease in Older Age. Arnould L, Soumaré A, D'Aoust T, Lima Rebouças SC, Bordes C, Crivello F, Korobelnik JF, Paques M, Sargurupremraj M, Mishra A, Zhu YC, Delcourt C, Helmer C, Khawaja A, Hysi P, Binquet C, Creuzot-Garcher C, Debette S. Erratum for Neurology. 2025 Nov 11;105(9):e214251. doi: 10.1212/WNL.0000000000214251. DOI: 10.1212/WNL.0000000000214551 PMID: 42585613]]></description>
		
		
		
			</item>
		<item>
		<title>Dynamical system modeling in schizophrenia: a narrative review of computational psychiatry frameworks</title>
		<link>https://www.bordeaux-neurocampus.fr/en/article/dynamical-system-modeling-in-schizophrenia-a-narrative-review-of-computational-psychiatry-frameworks/</link>
		
		<dc:creator><![CDATA[Arnaud Rodriguez]]></dc:creator>
		<pubDate>Sun, 06 Sep 2026 00:00:00 +0000</pubDate>
				<guid isPermaLink="false">https://www.bordeaux-neurocampus.fr/?post_type=article&#038;p=206117</guid>

					<description><![CDATA[1. Dialogues Clin Neurosci. 2026 Dec;28(1):327-342. doi: 10.1080/19585969.2026.2724875. Epub 2026 Sep 6. Dynamical system modeling in schizophrenia: a narrative review of computational psychiatry frameworks. Soydemir H(1), Gauld C(2), Desroches M(3)(4), Pignon B(5), Depannemaecker D(1). Author information: (1)Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France. (2)SANPSY, CNRS, UMR 6033, Service de psychopathologie du développement, Hospices Civils de Lyon, Bordeaux, France. (3)Inria Branch at the University of Montpellier, Montpellier, France. (4)Basque Center for Applied Mathematics, Bilbao, Spain. (5)APHP, Paris, France. The temporal evolution of schizophrenia symptoms is inherently complex and non-linear. Clinical states fluctuate between relatively stable and highly disorganised&#8230;]]></description>
		
		
		
			</item>
		<item>
		<title>Astrocytic PI3Kα controls synaptic plasticity and cognitive function via serine metabolism</title>
		<link>https://www.bordeaux-neurocampus.fr/en/article/astrocytic-pi3k%ce%b1-controls-synaptic-plasticity-and-cognitive-function-via-serine-metabolism/</link>
		
		<dc:creator><![CDATA[Arnaud Rodriguez]]></dc:creator>
		<pubDate>Fri, 04 Sep 2026 00:00:00 +0000</pubDate>
				<guid isPermaLink="false">https://www.bordeaux-neurocampus.fr/?post_type=article&#038;p=206157</guid>

					<description><![CDATA[]]></description>
		
		
		
			</item>
		<item>
		<title>Anterior cingulate cortex engram drives Post traumatic stress disorder-like memory impairments in a rodent model of traumatic fear</title>
		<link>https://www.bordeaux-neurocampus.fr/en/article/anterior-cingulate-cortex-engram-drives-post-traumatic-stress-disorder-like-memory-impairments-in-a-rodent-model-of-traumatic-fear/</link>
		
		<dc:creator><![CDATA[Arnaud Rodriguez]]></dc:creator>
		<pubDate>Fri, 04 Sep 2026 00:00:00 +0000</pubDate>
				<guid isPermaLink="false">https://www.bordeaux-neurocampus.fr/?post_type=article&#038;p=206134</guid>

					<description><![CDATA[Abstract Fear memories in post-traumatic stress disorder are marked by persistent cue-driven recollection and impaired contextual recall, yet the engram organization underlying this maladaptive state remains unclear. Here we used a rodent model combining contextual fear conditioning with systemic corticosterone to mimic trauma-associated glucocorticoid exposure. This paradigm generated a PTSD-like phenotype characterized by hypermnesia for a trauma-related but irrelevant (non-predictive of the threat) cue and contextual amnesia. Activity-dependent tagging and reactivation mapping revealed that traumatic memory is supported by a regionally dysregulated engram pattern, with enhanced recruitment of the anterior cingulate cortex (ACC) and basolateral amygdala (BLA), and reduced engagement&#8230;]]></description>
		
		
		
			</item>
		<item>
		<title>Fifteen‐Year Outcomes of Bilateral Pallidal Stimulation in Isolated Generalized Dystonia: Characterization of Therapeutic Response and Emergence of Parkinsonism</title>
		<link>https://www.bordeaux-neurocampus.fr/en/article/fifteen%e2%80%90year-outcomes-of-bilateral-pallidal-stimulation-in-isolated-generalized-dystonia-characterization-of-therapeutic-response-and-emergence-of-parkinsonism/</link>
		
		<dc:creator><![CDATA[Arnaud Rodriguez]]></dc:creator>
		<pubDate>Thu, 03 Sep 2026 00:00:00 +0000</pubDate>
				<guid isPermaLink="false">https://www.bordeaux-neurocampus.fr/article/fifteen%e2%80%90year-outcomes-of-bilateral-pallidal-stimulation-in-isolated-generalized-dystonia-characterization-of-therapeutic-response-and-emergence-of-parkinsonism/</guid>

					<description><![CDATA[Abstract Background Bilateral pallidal deep brain stimulation ( GPi ‐ DBS ) is effective for dystonia. Long‐term evolution of therapeutic benefit and emergence of parkinsonism have not been systematically characterized. Objectives To assess 15‐year dystonia outcomes and characterize parkinsonism after bilateral GPi ‐ DBS . Methods Dystonia severity and disability were evaluated at baseline,1, 3, and 15 years postoperatively with the Burke–Fahn–Marsden Dystonia Rating Scale (BFMDRS). Parkinsonism was assessed at last visit using the Movement Disorder Society‐Unified Parkinson's Disease Rating Scale‐Part III and freezing of gait (FoG) questionnaire. Results Of 17 patients reassessed at 15 years, 41% maintained clinical benefit. Parkinsonism was&#8230;]]></description>
		
		
		
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