Effects of clozapine on perceptual abnormalities and sensory gating: A preliminary cross-sectional study in schizophrenia
Journal of Clinical Psychopharmacology. 2015-04-01; 35(2): 184-187
DOI: 10.1097/JCP.0000000000000270
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1. J Clin Psychopharmacol. 2015 Apr;35(2):184-7. doi: 10.1097/JCP.0000000000000270.
Effects of clozapine on perceptual abnormalities and sensory gating: a
preliminary cross-sectional study in schizophrenia.
Micoulaud-Franchi JA(1), Aramaki M, Geoffroy PA, Richieri R, Cermolacce M, Faget
C, Ystad S, Kronland-Martinet R, Lancon C, Vion-Dury J.
Author information:
(1)From the *Pôle de Psychiatrie “Solaris,” and †Unité de Neurophysiologie et
Psychophysiologie, Pôle de Psychiatrie Universitaire, Centre Hospitalier
Universitaire de Sainte Marguerite; ‡Laboratoire de Neurosciences Cognitives,
Unité Mixte de Recherche Centre National de la Recherche Scientifique 7291;
§Laboratoire de Mécanique et d’Acoustique, Centre National de la Recherche
Scientifique, Unité Propre de Recherche 7051, Aix Marseille Université, Centrale
Marseille, Marseille; ∥Inserm, Unité Mixte de Recherche, Institut National de la
Santé et de la Recherche Médicale 1144, Paris; Fondation Fondamental, Créteil;
¶Assistance Publique Hôpitaux de Paris, Groupe Hospitalier Saint Louis,
Lariboisière, Fernand Widal, Pôle Neurosciences; #Université Paris Descartes;
**Université Paris Diderot, Paris; and ††Laboratoire de Santé Publique Évaluation
des Systèmes de Soins et Santé Perçue, Faculté de Médecine, Université de la
Méditerranée, Equipe d’Accueil 3279, Marseille, France.
The aim of the present study was to investigate the effect of second-generation
antipsychotics (clozapine or another second-generation antipsychotic) on
perceptual abnormalities related to sensory gating deficit. Although clozapine is
known to improve sensory gating assessed neurophysiologically, we hypothesized
that patients with schizophrenia treated with clozapine would report less
perceptual abnormalities related to sensory gating deficit than patients treated
with other second-generation antipsychotics do. Forty patients with a diagnosis
of schizophrenia were investigated (10 patients treated with clozapine and 30
patients treated with another second-generation antipsychotic drug). Perceptual
abnormalities were assessed with the Sensory Gating Inventory. Sensory gating was
assessed through electroencephalogram with the auditory event-related potential
method by measuring P50 amplitude changes in a dual click conditioning-testing
procedure. Patients treated with clozapine present normal sensory gating and
report less perceptual abnormalities related to sensory gating than patients
treated with other second-generation antipsychotics do. Although the
cross-sectional design of this study is limited because causal inferences cannot
be clearly concluded, the present study suggests clinical and neurophysiological
advantages of clozapine compared with other second-generation antipsychotics and
provides a basis for future investigations on the effect of this treatment on
perceptual abnormalities related to sensory gating deficit in patients with
schizophrenia.
DOI: 10.1097/JCP.0000000000000270
PMID: 25587694 [Indexed for MEDLINE]