Diffusion tensor fiber tracking shows distinct corticostriatal circuits in humans.
Ann Neurol.. 2004-03-22; 55(4): 522-529
DOI: 10.1002/ana.20030
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1. Ann Neurol. 2004 Apr;55(4):522-9.
Diffusion tensor fiber tracking shows distinct corticostriatal circuits in
humans.
Lehéricy S(1), Ducros M, Van de Moortele PF, Francois C, Thivard L, Poupon C,
Swindale N, Ugurbil K, Kim DS.
Author information:
(1)Center for Magnetic Resonance Research, University of Minnesota Medical
School, Minneapolis, MN, USA.
A landmark of corticostriatal connectivity in nonhuman primates is that cortical
connections are organized into a set of discrete circuits. Each circuit is
assumed to perform distinct behavioral functions. In animals, most connectivity
studies are performed using invasive tracing methods, which are nonapplicable in
humans. To test the proposal that corticostriatal connections are organized as
multiple circuits in humans, we used diffusion tensor imaging axonal tracking, a
new magnetic resonance technique that allows demonstration of fiber tracts in a
noninvasive manner. Diffusion tensor imaging-based fiber tracking showed that the
posterior (sensorimotor), anterior (associative), and ventral (limbic)
compartments of the human striatum have specific connections with the cortex, and
particularly the frontal lobes. These results provide the first direct
demonstration of distinct corticostriatal connections in humans.
DOI: 10.1002/ana.20030
PMID: 15048891 [Indexed for MEDLINE]