Development of an implantable microstimulation system for chronic DBS in rodents
2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2011-08-01; :
DOI: 10.1109/IEMBS.2011.6090147
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1. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:660-2. doi:
10.1109/IEMBS.2011.6090147.
Development of an implantable microstimulation system for chronic DBS in rodents.
Paulat R(1), Meissner W, Morgenstern R, Kupsch A, Harnack D.
Author information:
(1)Medical and Technical Laboratories, Biomedical Research Center,
Charité-Universitätsmedizin Berlin, Campus Virchow, Berlin, Germany. raik.paulat@
charite.de
High frequency deep brain stimulation (DBS) of certain basal ganglia nuclei (e.g.
subthalamic nucleus, STN) has emerged as a powerful neuromodulatory approach in
the treatment of late stage Parkinson’s disease patients. However, the underlying
mechanisms of action are not fully understood. We have therefore established an
implantable DBS device for small laboratory animals (e.g. rats) that allows the
reliable and safe application of continuous DBS for at least 3 weeks. We could
further show that miniaturized monopolar electrodes comprising activated iridium
are suitable for continuous stimulation of small brain structures like the STN
without inducing severe insertion or stimulation related injuries.
DOI: 10.1109/IEMBS.2011.6090147
PMID: 22254395 [Indexed for MEDLINE]