Deep brain stimulation in dystonia
Journal of Neurology. 2003-10-01; 250(10): 1201-1205
DOI: 10.1007/s00415-003-0179-0
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1. J Neurol. 2003 Oct;250(10):1201-5.
The effects of frequency in pallidal deep brain stimulation for primary dystonia.
Kupsch A(1), Klaffke S, Kühn AA, Meissner W, Arnold G, Schneider GH, Maier-Hauff
K, Trottenberg T.
Author information:
(1)Dept. of Neurology, Charité, Campus Virchow, Humboldt University Berlin,
Augustenburger Platz 1, 13353 Berlin, Germany.
Erratum in
J Neurol. 2004 Aug;251(8):1031.
The effect of stimulation frequency for pallidal deep brain stimulation in five
patients with either generalized or segmental dystonia was evaluated three to
twelve months postoperatively via a randomized, double-blind paradigm. The
quality of life and the severity of dystonic symptoms improved by approximately
60% and 43% respectively using a frequency of 130 Hz. Compared with 130 Hz a
significant further clinical improvement was observed at frequencies of 180 and
250 Hz, which contrasted with a significant deterioration at lower frequencies
(5, 50 Hz) compared to 130 Hz.
DOI: 10.1007/s00415-003-0179-0
PMID: 14586602 [Indexed for MEDLINE]