D5 dopamine receptors control glutamatergic AMPA transmission between the motor cortex and subthalamic nucleus
Sci Rep. 2018-06-11; 8(1):
DOI: 10.1038/s41598-018-27195-6
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1. Sci Rep. 2018 Jun 11;8(1):8858. doi: 10.1038/s41598-018-27195-6.
D5 dopamine receptors control glutamatergic AMPA transmission between the motor
cortex and subthalamic nucleus.
Froux L(1)(2), Le Bon-Jego M(1)(2), Miguelez C(3)(4), Normand E(5)(6), Morin
S(1)(2), Fioramonti S(1)(2), Barresi M(1)(2), Frick A(7)(8), Baufreton J(1)(2),
Taupignon A(9)(10).
Author information:
(1)Univ. de Bordeaux, Institut des Maladies Neurodegeneratives, UMR 5293,
F-33000, Bordeaux, France.
(2)CNRS, Institut des Maladies Neurodegeneratives, UMR 5293, F-33000, Bordeaux,
France.
(3)Department of Pharmacology, Faculty of Medicine and Dentistry, University of
the Basque Country (UPV/EHU), 48940, Leioa, Spain.
(4)Department of Pharmacology, Faculty of Pharmacy, University of the Basque
Country (UPV/EHU), 01006, Vitoria-Gasteiz, Spain.
(5)Univ. de Bordeaux, Institut Interdisciplinaire des Neurosciences, UMR 5297,
F-33000, Bordeaux, France.
(6)CNRS, Institut Interdisciplinaire des Neurosciences, UMR 5297, F-33000,
Bordeaux, France.
(7)INSERM, Neurocentre Magendie, Physiopathologie de la plasticité neuronale,
U1215, 33077, Bordeaux cedex, France.
(8)Univ. Bordeaux, Neurocentre Magendie, Physiopathologie de la plasticité
neuronale, U1215, 33077, Bordeaux, cedex, France.
(9)Univ. de Bordeaux, Institut des Maladies Neurodegeneratives, UMR 5293,
F-33000, Bordeaux, France. .
(10)CNRS, Institut des Maladies Neurodegeneratives, UMR 5293, F-33000, Bordeaux,
France. .
Corticofugal fibers target the subthalamic nucleus (STN), a component nucleus of
the basal ganglia, in addition to the striatum, their main input. The
cortico-subthalamic, or hyperdirect, pathway, is thought to supplement the
cortico-striatal pathways in order to interrupt/change planned actions. To
explore the previously unknown properties of the neurons that project to the STN,
retrograde and anterograde tools were used to specifically identify them in the
motor cortex and selectively stimulate their synapses in the STN. The
cortico-subthalamic neurons exhibited very little sag and fired an initial
doublet followed by non-adapting action potentials. In the STN, AMPA/kainate
synaptic currents had a voltage-dependent conductance, indicative of
GluA2-lacking receptors and were partly inhibited by Naspm. AMPA transmission
displayed short-term depression, with the exception of a limited bandpass in the
5 to 15 Hz range. AMPA synaptic currents were negatively controlled by dopamine
D5 receptors. The reduction in synaptic strength was due to postsynaptic D5
receptors, mediated by a PKA-dependent pathway, but did not involve a modified
rectification index. Our data indicated that dopamine, through post-synaptic D5
receptors, limited the cortical drive onto STN neurons in the normal brain.
DOI: 10.1038/s41598-018-27195-6
PMCID: PMC5995923
PMID: 29891970