Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids.
Philosophical Transactions of the Royal Society B: Biological Sciences. 2012-10-29; 367(1607): 3254-3263
DOI: 10.1098/rstb.2011.0384
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1. Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3254-63. doi:
10.1098/rstb.2011.0384.
Cellular and intracellular mechanisms involved in the cognitive impairment of
cannabinoids.
Puighermanal E(1), Busquets-Garcia A, Maldonado R, Ozaita A.
Author information:
(1)Departament de Ciències Experimentals i de la Salut, Facultat de Ciències de
la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain.
Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the
modulation of endogenous cannabinoids, affect cognitive function through the
activation of cannabinoid receptors. Indeed, these compounds modulate a number of
signalling pathways critically implicated in the deleterious effect of
cannabinoids on learning and memory. Thus, the involvement of the mammalian
target of rapamycin pathway and extracellular signal-regulated kinases, together
with their consequent regulation of cellular processes such as protein
translation, play a critical role in the amnesic-like effects of cannabinoids. In
this study, we summarize the cellular and molecular mechanisms reported in the
modulation of cognitive function by the endocannabinoid system.
DOI: 10.1098/rstb.2011.0384
PMCID: PMC3481526
PMID: 23108544 [Indexed for MEDLINE]