Cannabinoid type-1 receptors in the paraventricular nucleus of the hypothalamus inhibit stimulated food intake.
Neuroscience. 2014-03-01; 263: 46-53
DOI: 10.1016/j.neuroscience.2014.01.005
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1. Neuroscience. 2014 Mar 28;263:46-53. doi: 10.1016/j.neuroscience.2014.01.005.
Epub 2014 Jan 13.
Cannabinoid type-1 receptors in the paraventricular nucleus of the hypothalamus
inhibit stimulated food intake.
Soria-Gómez E(1), Massa F(2), Bellocchio L(2), Rueda-Orozco PE(3), Ciofi P(2),
Cota D(2), Oliet SH(2), Prospéro-García O(3), Marsicano G(4).
Author information:
(1)INSERM U862 NeuroCentre Magendie, Bordeaux, France; Université de Bordeaux,
Bordeaux, France. Electronic address: .
(2)INSERM U862 NeuroCentre Magendie, Bordeaux, France; Université de Bordeaux,
Bordeaux, France.
(3)Grupo de Cannabinoides, Facultad de Medicina, UNAM, México City, Mexico.
(4)INSERM U862 NeuroCentre Magendie, Bordeaux, France; Université de Bordeaux,
Bordeaux, France. Electronic address: .
Cannabinoid receptor type 1 (CB1)-dependent signaling in the brain is known to
modulate food intake. Recent evidence has actually shown that CB1 can both
inhibit and stimulate food intake in fasting/refeeding conditions, depending on
the specific neuronal circuits involved. However, the exact brain sites where
this bimodal control is exerted and the underlying neurobiological mechanisms are
not fully understood yet. Using pharmacological and electrophysiological
approaches, we show that local CB1 blockade in the paraventricular nucleus of the
hypothalamus (PVN) increases fasting-induced hyperphagia in rats. Furthermore,
local CB1 blockade in the PVN also increases the orexigenic effect of the gut
hormone ghrelin in animals fed ad libitum. At the electrophysiological level, CB1
blockade in slices containing the PVN potentiates the decrease of the activity of
PVN neurons induced by long-term application of ghrelin. Hence, the PVN is (one
of) the site(s) where signals associated with the body’s energy status determine
the direction of the effects of endocannabinoid signaling on food intake.
Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.neuroscience.2014.01.005
PMID: 24434770 [Indexed for MEDLINE]