Cancer pain is not necessarily correlated with spinal overexpression of reactive glia markers.
Pain. 2014-02-01; 155(2): 275-291
DOI: 10.1016/j.pain.2013.10.008
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1. Pain. 2014 Feb;155(2):275-291. doi: 10.1016/j.pain.2013.10.008. Epub 2013 Oct 11.
Cancer pain is not necessarily correlated with spinal overexpression of reactive
glia markers.
Ducourneau VRR(1), Dolique T, Hachem-Delaunay S, Miraucourt LS, Amadio A,
Blaszczyk L, Jacquot F, Ly J, Devoize L, Oliet SHR, Dallel R, Mothet JP, Nagy F,
Fénelon VS, Voisin DL.
Author information:
(1)Neurocentre Magendie, INSERM U862, F-33000 Bordeaux, France Université
Bordeaux, F-33000 Bordeaux, France CNRS, IINS, UMR5297, F-33000 Bordeaux, France
Clermont Université, Université d’Auvergne, NEURO-DOL, BP 10448, F-63000
Clermont-Ferrand, France Inserm, U1107, F-63001 Clermont-Ferrand, France.
Bone cancer pain is a common and disruptive symptom in cancer patients. In cancer
pain animal models, massive reactive astrogliosis in the dorsal horn of the
spinal cord has been reported. Because astrocytes may behave as driving partners
for pathological pain, we investigated the temporal development of pain behavior
and reactive astrogliosis in a rat bone cancer pain model induced by injecting
MRMT-1 rat mammary gland carcinoma cells into the tibia. Along with the
development of bone lesions, a gradual mechanical and thermal allodynia and
hyperalgesia as well as a reduced use of the affected limb developed in bone
cancer-bearing animals, but not in sham-treated animals. Dorsal horn Fos
expression after nonpainful palpation of the injected limb was also increased in
bone cancer-bearing animals. However, at any time during the evolution of tumor,
there was no increase in glial fibrillary acidic protein (GFAP) immunoreactivity
in the dorsal horn. Further analysis at 21days after injection of the tumor
showed no increase in GFAP and interleukin (IL) 1β transcripts, number of
superficial dorsal horn S100β protein immunoreactive astrocytes, or
immunoreactivity for microglial markers (OX-42 and Iba-1). In contrast, all these
parameters were increased in the dorsal horn of rats 2weeks after sciatic nerve
ligation. This suggests that in some cases, bone cancer pain may not be
correlated with spinal overexpression of reactive glia markers, whereas
neuropathic pain is. Glia may thus play different roles in the development and
maintenance of chronic pain in these 2 situations.
Copyright © 2013 International Association for the Study of Pain. Published by
Elsevier B.V. All rights reserved.
DOI: 10.1016/j.pain.2013.10.008
PMID: 24120461 [Indexed for MEDLINE]