BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks.
Science. 2015-06-11; 348(6240): 1241-1244
DOI: 10.1126/science.1255905
Read on PubMed
1. Science. 2015 Jun 12;348(6240):1241-4. doi: 10.1126/science.1255905. Epub 2015
Jun 11.
BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain
networks.
Richiardi J(1), Altmann A(2), Milazzo AC(3), Chang C(4), Chakravarty MM(5),
Banaschewski T(6), Barker GJ(7), Bokde AL(8), Bromberg U(9), Büchel C(9), Conrod
P(10), Fauth-Bühler M(11), Flor H(12), Frouin V(13), Gallinat J(14), Garavan
H(15), Gowland P(16), Heinz A(14), Lemaître H(17), Mann KF(11), Martinot JL(17),
Nees F(12), Paus T(18), Pausova Z(19), Rietschel M(20), Robbins TW(21), Smolka
MN(22), Spanagel R(23), Ströhle A(14), Schumann G(24), Hawrylycz M(25), Poline
JB(26), Greicius MD(27); IMAGEN consortium.
Collaborators: Albrecht L, Andrew C, Arroyo M, Artiges E, Aydin S, Bach C,
Banaschewski T, Barbot A, Barker G, Boddaert N, Bokde A, Bricaud Z, Bromberg U,
Bruehl R, Büchel C, Cachia A, Cattrell A, Conrod P, Constant P, Dalley J,
Decideur B, Desrivieres S, Fadai T, Flor H, Frouin V, Gallinat J, Garavan H,
Gollier Briand F, Gowland P, Heinrichs B, Heinz A, Heym N, Hübner T, Ireland J,
Ittermann B, Jia T, Lathrop M, Lanzerath D, Lawrence C, Lemaitre H, Lüdemann K,
Macare C, Mallik C, Mangin JF, Mann K, Martinot JL, Mennigen E, Mesquita de
Carvahlo F, Mignon X, Miranda R, Müller K, Nees F, Nymberg C, Paillere ML, Paus
T, Pausova Z, Poline JB, Poustka L, Rapp M, Robert G, Reuter J, Rietschel M,
Ripke S, Robbins T, Rodehacke S, Rogers J, Romanowski A, Ruggeri B, Schmäl C,
Schmidt D, Schneider S, Schumann M, Schubert F, Schwartz Y, Smolka M, Sommer W,
Spanagel R, Speiser C, Spranger T, Stedman A, Steiner S, Stephens D, Strache N,
Ströhle A, Struve M, Subramaniam N, Topper L, Walter, Whelan R, Williams S,
Yacubian J, Zilbovicius M, Wong CP, Lubbe S, Martinez-Medina L, Fernandes A,
Tahmasebi A.
Author information:
(1)Functional Imaging in Neuropsychiatric Disorders Laboratory, Department of
Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Laboratory of Neurology and Imaging of Cognition, Department of Neuroscience,
University of Geneva, Geneva, Switzerland.
.
(2)Functional Imaging in Neuropsychiatric Disorders Laboratory, Department of
Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
(3)The War Related Illness and Injury Study Center, VA Palo Alto Health Care
System, Palo Alto, CA, USA. Functional Imaging in Neuropsychiatric Disorders
Laboratory, Department of Neurology and Neurological Sciences, Stanford
University, Stanford, CA, USA.
(4)Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National
Institute of Neurological Disorders and Stroke, National Institutes of Health,
Bethesda, MD, USA.
(5)Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal,
Canada. Departments of Psychiatry and Biomedical Engineering, McGill University,
Montreal, Canada.
(6)Department of Child and Adolescent Psychiatry, Central Institute of Mental
Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
(7)Institute of Psychiatry, Psychology and Neuroscience, King’s College London,
London, UK.
(8)Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
(9)Universitaetsklinikum Hamburg Eppendorf, Hamburg, Germany.
(10)Institute of Psychiatry, Psychology and Neuroscience, King’s College London,
London, UK. Department of Psychiatry, Université de Montréal, Centre Hospitalier
Universitaire (CHU) Ste Justine Hospital, Montréal, Canada.
(11)Department of Addictive Behaviour and Addiction Medicine, Central Institute
of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim,
Germany.
(12)Department of Cognitive and Clinical Neuroscience, Central Institute of
Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim,
Germany.
(13)Neurospin, Commissariat à l’Energie Atomique et aux Energies Alternatives,
Paris, France.
(14)Department of Psychiatry and Psychotherapy, Campus Charité Mitte,
Charité-Universitätsmedizin Berlin, Berlin, Germany.
(15)Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT,
USA.
(16)School of Physics and Astronomy, University of Nottingham, Nottingham, UK.
(17)Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000
“Neuroimaging and Psychiatry,” University Paris Sud, Orsay, France. INSERM Unit
1000 at Maison de Solenn, Assistance Publique Hôpitaux de Paris (APHP), Cochin
Hospital, University Paris Descartes, Sorbonne Paris Cité, Paris, France.
(18)Rotman Research Institute, University of Toronto, Toronto, Canada. School of
Psychology, University of Nottingham, Nottingham, UK.
(19)The Hospital for Sick Children, University of Toronto, Toronto, Canada.
(20)Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental
Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
(21)Behavioural and Clinical Neuroscience Institute and Department of Psychology,
University of Cambridge, Cambridge, UK.
(22)Department of Psychiatry and Psychotherapy, and Neuroimaging Center,
Technische Universität Dresden, Dresden, Germany.
(23)Department of Psychopharmacology, Central Institute of Mental Health, Faculty
of Clinical Medicine Mannheim, Mannheim, Germany.
(24)Institute of Psychiatry, Psychology and Neuroscience, King’s College London,
London, UK. Medical Research Council (MRC) Social, Genetic and Developmental
Psychiatry (SGDP) Centre, London, UK.
(25)Allen Institute for Brain Science, Seattle, WA, USA.
(26)Helen Wills Neuroscience Institute, University of California Berkeley,
Berkeley, CA, USA.
(27)Functional Imaging in Neuropsychiatric Disorders Laboratory, Department of
Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
.
During rest, brain activity is synchronized between different regions widely
distributed throughout the brain, forming functional networks. However, the
molecular mechanisms supporting functional connectivity remain undefined. We show
that functional brain networks defined with resting-state functional magnetic
resonance imaging can be recapitulated by using measures of correlated gene
expression in a post mortem brain tissue data set. The set of 136 genes we
identify is significantly enriched for ion channels. Polymorphisms in this set of
genes significantly affect resting-state functional connectivity in a large
sample of healthy adolescents. Expression levels of these genes are also
significantly associated with axonal connectivity in the mouse. The results
provide convergent, multimodal evidence that resting-state functional networks
correlate with the orchestrated activity of dozens of genes linked to ion channel
activity and synaptic function.
Copyright © 2015, American Association for the Advancement of Science.
DOI: 10.1126/science.1255905
PMCID: PMC4829082
PMID: 26068849 [Indexed for MEDLINE]