Bilateral subthalamic nucleus stimulation for severe Parkinson’s disease
Mov Disord.. 1995-09-01; 10(5): 672-674
DOI: 10.1002/mds.870100523
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1. Mov Disord. 1995 Sep;10(5):672-4. doi: 10.1002/mds.870100523.
Bilateral subthalamic nucleus stimulation for severe Parkinson’s disease.
Limousin P(1), Pollak P, Benazzouz A, Hoffmann D, Broussolle E, Perret JE,
Benabid AL.
Author information:
(1)Department of Clinical and Biological Neurosciences, Joseph Fourier
University of Grenoble, France.
Subthalamic nucleus (STN) lesions or high-frequency stimulations could improve
parkinsonian symptoms in monkeys treated by MPTP. We have applied the procedure
of chronic stimulation to the STN in severely disabled parkinsonian patients.
This article presents the case of the first patient operated on bilaterally.
Bilateral STN stimulation has greatly improved akinesia and rigidity. The
benefit was maintained < or = 15 months after surgery. Unilateral stimulation
induced motor effects mainly in contralateral limbs. Further studies are needed
to evaluate the value of this procedure in the treatment of Parkinson's disease.
DOI: 10.1002/mds.870100523
PMID: 8552123 [Indexed for MEDLINE]