Astroglial type-1 cannabinoid receptor (CB1): A new player in the tripartite synapse.
Neuroscience. 2016-05-01; 323: 35-42
DOI: 10.1016/j.neuroscience.2015.05.002
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1. Neuroscience. 2016 May 26;323:35-42. doi: 10.1016/j.neuroscience.2015.05.002.
Epub 2015 May 9.
Astroglial type-1 cannabinoid receptor (CB1): A new player in the tripartite
synapse.
Oliveira da Cruz JF(1), Robin LM(2), Drago F(3), Marsicano G(4), Metna-Laurent
M(5).
Author information:
(1)INSERM U862 NeuroCentre Magendie, INSERM, 146 rue Leo Saignat, 33077 Bordeaux,
France; University of Bordeaux, 146 rue Leo Saignat, 33077 Bordeaux, France;
Dept. of Clinical and Molecular Biomedicine, Section of Pharmacology and
Biochemistry, University of Catania, Catania, Italy.
(2)INSERM U862 NeuroCentre Magendie, INSERM, 146 rue Leo Saignat, 33077 Bordeaux,
France; University of Bordeaux, 146 rue Leo Saignat, 33077 Bordeaux, France.
(3)Dept. of Clinical and Molecular Biomedicine, Section of Pharmacology and
Biochemistry, University of Catania, Catania, Italy.
(4)INSERM U862 NeuroCentre Magendie, INSERM, 146 rue Leo Saignat, 33077 Bordeaux,
France; University of Bordeaux, 146 rue Leo Saignat, 33077 Bordeaux, France.
Electronic address: .
(5)INSERM U862 NeuroCentre Magendie, INSERM, 146 rue Leo Saignat, 33077 Bordeaux,
France; University of Bordeaux, 146 rue Leo Saignat, 33077 Bordeaux, France.
Electronic address: .
The endocannabinoid system is an important regulator of physiological functions.
In the brain, this control is mainly exerted through the type-1-cannabinoid (CB1)
receptors. CB1 receptors are abundant at neuron terminals where their stimulation
inhibits neurotransmitter release. However, CB1 receptors are also expressed in
astrocytes and recent studies showed that astroglial cannabinoid signaling is a
key element of the tripartite synapse. In this review we discuss the different
mechanisms by which astroglial CB1 receptors control synaptic transmission and
plasticity. The recent involvement of astroglial CB1 receptors in the effects of
cannabinoids on memory highlights their key roles in cognitive processes and
further indicates that astrocytes are central active elements of high-order brain
functions.
Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.neuroscience.2015.05.002
PMID: 25967266 [Indexed for MEDLINE]