Association of metabolic syndrome with sensory gating deficits in patients with chronic schizophrenia
Psychoneuroendocrinology. 2015-07-01; 57: 125-133
DOI: 10.1016/j.psyneuen.2015.04.005
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1. Psychoneuroendocrinology. 2015 Jul;57:125-33. doi:
10.1016/j.psyneuen.2015.04.005. Epub 2015 Apr 15.
Association of metabolic syndrome with sensory gating deficits in patients with
chronic schizophrenia.
Micoulaud-Franchi JA(1), Faugere M(2), Boyer L(3), Cermolacce M(4), Richieri
R(2), Faget C(2), Philip P(5), Vion-Dury J(4), Lancon C(2).
Author information:
(1)Unité de Neurophysiologie et Psychophysiologie, Pôle de Psychiatrie
Universitaire, CHU Sainte-Marguerite, 270 Bd Sainte-Marguerite, 13009 Marseille,
France; Services d’explorations fonctionnelles du système nerveux, Clinique du
sommeil, CHU de Bordeaux, Place Amélie Raba-Leon, 33076 Bordeaux, France; USR
CNRS 3413 SANPSY, CHU Pellegrin, Université de Bordeaux, Talence, France.
Electronic address: .
(2)Pôle de Psychiatrie “Solaris”, Centre Hospitalier Universitaire de
Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France;
Laboratoire de santé publique évaluation des systèmes de soins et santé perçue,
Université de la Méditerranée – EA 3279 – Faculté de Médecine, 27 bd Jean Moulin,
13385 Marseille Cedex 05, France.
(3)Laboratoire de santé publique évaluation des systèmes de soins et santé
perçue, Université de la Méditerranée – EA 3279 – Faculté de Médecine, 27 bd Jean
Moulin, 13385 Marseille Cedex 05, France.
(4)Unité de Neurophysiologie et Psychophysiologie, Pôle de Psychiatrie
Universitaire, CHU Sainte-Marguerite, 270 Bd Sainte-Marguerite, 13009 Marseille,
France; Pôle de Psychiatrie “Solaris”, Centre Hospitalier Universitaire de
Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France;
Laboratoire de Neurosciences Cognitives (LNC), UMR CNRS 7291, 31 Aix-Marseille
Université, Site St Charles, 3 place Victor Hugo, 13331 Marseille Cedex 3,
France.
(5)Services d’explorations fonctionnelles du système nerveux, Clinique du
sommeil, CHU de Bordeaux, Place Amélie Raba-Leon, 33076 Bordeaux, France; USR
CNRS 3413 SANPSY, CHU Pellegrin, Université de Bordeaux, Talence, France.
Metabolic syndrome is more prevalent in schizophrenia than in the general
population and is associated with an increased rate of morbidity. It has been
associated with cognitive impairments in schizophrenia, which are a core deficit
in patients with chronic schizophrenia. Sensory gating deficit is also a core
deficit in schizophrenia. The principal objective of this study was to
investigate the relationship between sensory gating deficit and metabolic
syndrome in patients with schizophrenia, after adjusting for key confounding
factors. We hypothesized that patients with metabolic syndrome exhibit a higher
rate of sensory gating deficit compared to those without metabolic syndrome. This
study investigated sensory gating with the auditory event-related potential
method by measuring P50 amplitude changes in a double click conditioning-testing
procedure in 51 patients with schizophrenia. Patients with metabolic syndrome (n
= 14) had a higher rate of sensory gating deficit (P50 suppression