Adult hippocampal neurogenesis is involved in anxiety-related behaviors

J-M Revest, D Dupret, M Koehl, C Funk-Reiter, N Grosjean, P-V Piazza, D N Abrous
Mol Psychiatry. 2009-03-03; 14(10): 959-967
DOI: 10.1038/mp.2009.15

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Adult hippocampal neurogenesis is a unique example of structural plasticity, the functional role of which has been a matter of intense debate. New transgenic models have recently shown that neurogenesis participates in hippocampus-mediated
learning. Here, we show that transgenic animals, in which adult hippocampal neurogenesis has been specifically impaired, exhibit a striking increase in anxiety-related behaviors. Our results indicate that neurogenesis plays an important role in the regulation of affective states and could be the target of new treatments for anxiety disorders.

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