A Triad of Crystals Sheds Light on MDGA Interference with Neuroligation.
Neuron. 2017-08-01; 95(4): 729-732
DOI: 10.1016/j.neuron.2017.08.001
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1. Neuron. 2017 Aug 16;95(4):729-732. doi: 10.1016/j.neuron.2017.08.001.
A Triad of Crystals Sheds Light on MDGA Interference with Neuroligation.
Thoumine O(1), Marchot P(2).
Author information:
(1)Interdisciplinary Institute for Neuroscience, UMR 5297, Centre National de la
Recherche Scientifique, University of Bordeaux, 33000 Bordeaux, France.
Electronic address: .
(2)Centre National de la Recherche Scientifique, Aix-Marseille Université,
“Architecture et Fonction des Macromolécules Biologiques” laboratory, Faculté des
Sciences de Luminy, 13288 Marseille, France. Electronic address:
.
Neurexins and neuroligins form trans-synaptic complexes that promote synapse
development. In this issue of Neuron, Aricescu and colleagues (Elegheert et al.,
2017) complement and strengthen two recent reports by the Kim and Rudenko teams
(Kim et al., 2017; Gangwar et al., 2017) to dissect the molecular determinants by
which MDGAs challenge the neurexin-neuroligin partnership.
Copyright © 2017 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.neuron.2017.08.001
PMID: 28817794 [Indexed for MEDLINE]