Bordeaux Neurocampus Lecture – Marie-Pierre Moisan
Available in Replay
Inflammation-related depression: from symptoms dimensions to molecular biomarkers
Depression is the most common of mental disorders, representing the leading chronic condition and the first cause of years lived with disability. Mounting evidence suggests intricate bidirectional relationship between adiposity and depression, which may explain their similar and parallel growth. In the past decades, inflammation was revealed to be a key mediator of the relationship between adiposity and depression. The Nutripsy team has largely contributed to show that obesity and even obesogenic dietary habits are characterized by a low-grade inflammation that renders individuals vulnerable to neuropsychiatric symptoms. In this lecture, I will summarize recent clinical data from Nutripsy team reporting on detailed neuropsychiatric symptoms associated with inflammatory status according to obesity severity grades, the relative contribution of metabolic health and inflammation to depressive symptoms and the relationships of depressive symptoms with tryptophan metabolism. Then, I will present the results of a transcriptomic study comparing depressed and non-depressed obese subjects analyzed before and after a bariatric surgery revealing molecular pathways predictors of depressive symptoms intensity and of remission. This research programs aim to promote precision nutritional medicine applied to mental health, in a context where the efficacy of standard treatments remains mitigated.
Marie-Pierre Moisan defended her PhD in 1992 at the university of Ediburgh, UK. Her work was dedicated on the role of 11 beta hydroxysteroid dehydrogenase in the brain, an enzyme regenerating glucocorticoids from their inactive metabolite. She then did her postdoctoral research at Duke university (USA) where she focused on SF-1, a transcription factor critical for steroidogenesis . She secured a researcher position at INRA in the laboratory INSERM of Prof. Le Moal (Bordeaux, France) in 1993 to develop a project on the genetics of stress responses. In 2005 she spent one year at the University of Queensland, Australia where she worked on the regulation of the growth hormone receptor in obesity. Since her return to Bordeaux, she has been working at the laboratory Nutrineuro (Bordeaux, France) where she developed several lines of research aimed at understanding the interaction between nutrition, glucocorticoids and memory or depression. She has developed experimental approaches in preclinical models ranging from molecular analyses to behavioral assessments as well as clinical studies focusing on molecular biomarkers related to the role of glucocorticoid hormones. She is currently a INRAe research director and she is the co-leader of the Nutripsy team at Nutrineuro.
Marie-Pierre Moisan, Aline Foury, Sandra Dexpert, Steve Cole, Cédric Beau, Damien Forestier, Patrick Ledaguenel, Eric Magne & Lucile Capuron. Transcriptomic signaling pathways involved in a naturalistic model of inflammation-related depression and its remission. Translational Psychiatry, Nature Pub. Group, 2021, 11 (1), ⟨10.1038/s41398-021-01323-9⟩. ⟨hal-03190850⟩
Paola Tognini, Muntaha Samad, Kenichiro Kinouchi, Yu Liu, Jean-Christophe Helbling, Jean-Christophe Helbling, Marie-Pierre Moisan, Kristin Eckel-Mahan, Pierre Baldi, Paolo Sassone-Corsi.Reshaping circadian metabolism in the suprachiasmatic nucleus and prefrontal cortex by nutritional challenge. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2020, 117 (47), pp.29904-29913. ⟨10.1073/pnas.2016589117⟩. ⟨hal-03173039⟩
Essi Biyong, Serge Alfos, Fabien Dumetz, Jean-Christophe Helbling, Agnès Aubert, Julie Brossaud,Aline Foury, Marie-Pierre Moisan, et al.Dietary vitamin A supplementation prevents early obesogenic diet-induced microbiota, neuronal and cognitive alterations. International Journal of Obesity, Nature Publishing Group, In press, ⟨1038/s41366-020-00723-z⟩. ⟨hal-03046682⟩
Gabriela de Medeiros, Pauline Lafenetre, Yoottana Janthakhin, Juan-Carlos Cerpa, Chun-Lei Zhang, Marishka M. Mehta, Pierre Mortessagne, Jean-Christophe Helbling, Guillaume Ferreira, Marie-Pierre Moisan. Corticosteroid-binding globulin deficiency specifically impairs contextual and recognition memory consolidation in male mice. Neuroendocrinology, Karger, 2019, 109 (4), pp.322-332. ⟨10.1159/000499827⟩. ⟨hal-02618393⟩
Marion Rincel, Maïwenn Olier, Amandine Minni, Camille Monchaux de Oliveira, Yann Matime, Eric Gaultier, Isabelle Grit, Jean-Christophe Helbling, Anna Maria Costa, Amandine Lépinay, Marie-Pierre Moisan et al.Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation. Psychopharmacology, Springer Verlag, 2019, 236 (5), pp.1583-1596. ⟨1007/s00213-019-05252-w⟩. ⟨hal-02620346⟩
Freddy Jeanneteau, Christian Barrère, Mariska Vos, Carlie J.M. de Vries, Claude Rouillard, Daniel Levesque, Yann Dromard, Marie-Pierre Moisan,Vanja Duric, Tina C. Franklin, Ronald S. Duman, David A. Lewis, Stephen D. Ginsberg, Margarita Arango-Lievano. The stress-induced transcription factor NR4A1 adjusts mitochondrial function and synapse number in prefrontal cortex. Journal of Neuroscience, Society for Neuroscience, 2018, 38 (6), pp.1335-1350. ⟨10.1523/JNEUROSCI.2793-17.2017⟩. ⟨hal-02071089⟩
Nathalie Marissal-Arvy, Marie-Neige Campas, Audrey Sémont, Céline Ducroix-Crepy, Marie-Christine Beauvieux, Julie Brossaud, Jean-Benoît Corcuff, Jean-Christophe Helbling, Sylvie Vancassel, Anne-Karine Bouzier-Sore, Katia Touyarot, Guillaume Ferreira, Pascal Barat, Marie-Pierre Moisan.Insulin treatment partially prevents cognitive and hippocampal alterations as well as glucocorticoid dysregulation in early-onset insulin-deficient diabetic rats. Psychoneuroendocrinology, Elsevier, 2018, 93 (144), pp.72-81. ⟨10.1016/j.psyneuen.2018.04.016⟩. ⟨hal-02348253⟩
Julie Brossaud, Hélène Roumes, Jean-Christophe Helbling, Marie-Pierre Moisan, Véronique Pallet, et al.. Retinoic acid increases glucocorticoid receptor phosphorylation via cyclin-dependent kinase 5..Molecular and Cellular Neuroscience, Elsevier, 2017, 82, pp.96-104. ⟨1016/j.mcn.2017.05.001⟩. ⟨hal-01605008⟩
Aude Lagarrigue, Soufiane Ajana, Lucile Capuron, Catherine Féart, Marie-Pierre Moisan. Obesity in french inmates: gender differences and relationship with mood, eating behavior and physical activity.PLoS ONE, Public Library of Science, 2017, 12 (1), pp.1-14. ⟨1371/journal.pone.0170413⟩. ⟨hal-01602721⟩
Véronica Rougeon, Marie-Pierre Moisan, Nicole Barthe, Marie-Christine Beauvieux, Jean-Christophe Helbling, et al.. Diabetes and insulin injection modalities: effects on hepatic and hippocampal expression of 11β-hydroxysteroid dehydrogenase type 1 in juvenile diabetic male rats.Frontiers in Endocrinology, Frontiers, 2017, 8, pp.1-6. ⟨3389/fendo.2017.00081⟩. ⟨hal-01603874⟩