US Food and Drug Administration Approval of Aducanumab-Is Amyloid Load a Valid Surrogate End Point for Alzheimer Disease Clinical Trials?

MeSH terms

• Alzheimer Disease / drug therapy*
• Amyloid beta-Peptides / drug effects*
• Antibodies, Monoclonal, Humanized / therapeutic use*
• Biomarkers*
• Clinical Trials as Topic / standards*
• Drug Approval*
• Humans
• United States
• United States Food and Drug Administration