Leptin in energy balance and reward: two faces of the same coin?

Neuron. 2006 Sep 21;51(6):678-80. doi: 10.1016/j.neuron.2006.09.009.

Abstract

Leptin receptors are expressed on mesolimbic dopamine neurons, yet little is known about the functional significance of this anatomical relationship. In this issue of Neuron, Hommel et al. reveal a novel site for leptin's regulation of feeding. In turn, Fulton et al. propose a novel role for leptin in regulating non-feeding-related motivated behaviors.

Publication types

  • Comment

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Dopamine / metabolism
  • Feeding Behavior / drug effects
  • Feeding Behavior / physiology
  • Leptin / pharmacology*
  • Mesencephalon / cytology
  • Mesencephalon / drug effects
  • Mesencephalon / metabolism
  • Mice
  • Models, Biological
  • Neurons / drug effects
  • Neurons / metabolism
  • Neurons / physiology*
  • Phosphorylation / drug effects
  • Rats
  • Receptors, Cell Surface / physiology*
  • Receptors, Leptin
  • STAT3 Transcription Factor / metabolism
  • Signal Transduction / drug effects
  • Signal Transduction / physiology*
  • Ventral Tegmental Area / cytology
  • Ventral Tegmental Area / drug effects
  • Ventral Tegmental Area / metabolism

Substances

  • Leptin
  • Receptors, Cell Surface
  • Receptors, Leptin
  • STAT3 Transcription Factor
  • leptin receptor, mouse
  • Dopamine