[Involvement of hypothalamopituitary adrenal axis in abdominal obesity]

P Barat; M Duclos; M-P Moisan; P Mormède

doi:10.1016/j.arcped.2007.10.022

[Involvement of hypothalamopituitary adrenal axis in abdominal obesity]

Arch Pediatr. 2008 Feb;15(2):170-8. doi: 10.1016/j.arcped.2007.10.022. Epub 2008 Jan 16.

[Article in French]

Authors

P Barat¹, M Duclos, M-P Moisan, P Mormède

Affiliation

¹ Endocrinologie et diabétologie de l'enfant et de l'adolescent, hôpital des enfants, CHU de Bordeaux, place Amélie-Raba-Léon, Bordeaux cedex, France. pascal.barat@chu-bordeaux.fr

PMID: 18201880
DOI: 10.1016/j.arcped.2007.10.022

Abstract

Obesity is increasing worldwide. Abdominal obesity, which is due to the development of visceral adipose tissue, leads to metabolic disorders. Because abdominal obesity is associated with Cushing syndrome, many studies have been performed to find out how the hypothalamopituitary adrenal axis is involved in this disorder. Here, we propose to review these data before giving our experience on changes in hypothalamopituitary adrenal axis activity regarding fat mass distribution in prepubertal children.

Publication types

Comparative Study
Review

MeSH terms

11-beta-Hydroxysteroid Dehydrogenases / physiology
Abdominal Fat / metabolism*
Age Factors
Animals
Child
Disease Models, Animal
Ethnicity
Female
Humans
Hydrocortisone / metabolism
Hypothalamo-Hypophyseal System / physiology*
Insulin Resistance
Male
Metabolic Syndrome / metabolism
Metabolic Syndrome / physiopathology
Obesity / metabolism
Obesity / physiopathology*
Pituitary-Adrenal System / physiology*
Rats
Receptors, Glucocorticoid / physiology
Sex Factors

Substances

Receptors, Glucocorticoid
11-beta-Hydroxysteroid Dehydrogenases
Hydrocortisone