Circadian Sleep Propensity and Alcohol Interaction at the Wheel

J Clin Sleep Med. 2016 Jul 15;12(7):1011-7. doi: 10.5664/jcsm.5938.

Abstract

Study objectives: The study was aimed at estimating the effect of alcohol consumption, time of day, and their interaction on traffic crashes in a real regional context.

Methods: Blood alcohol concentration (BAC) data were collected from drivers involved in traffic accidents during one year in an Italian region and in a control group of drivers over the same road network. Mean circadian sleep propensity was estimated from a previous study as function of time of day. Accident risk was analyzed by logistic regression as function of BAC and circadian sleep propensity.

Results: BAC values greater than zero were found in 72.0% of the drivers involved in crashes and in 40.4% of the controls. Among the former 23.6% of the drivers exceeded the BAC legal threshold of 0.05 g/dL, while illegal values were found in 10.4% of the controls. The relative risk showed a significant increase with both BAC and circadian sleep propensity (as estimated from time of day) and their interaction was significant.

Conclusions: Due to the significant interaction, even low BAC levels strongly increased accident risk when associated with high sleep propensity.

Keywords: alcohol consumption; crash risk; driving; sleepiness.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Accidents, Traffic / statistics & numerical data*
  • Alcohol Drinking / epidemiology*
  • Automobile Driving*
  • Blood Alcohol Content*
  • Circadian Rhythm
  • Comorbidity
  • Humans
  • Italy
  • Sleep Deprivation / epidemiology*

Substances

  • Blood Alcohol Content