Conditional reduction of adult neurogenesis impairs bidirectional hippocampal synaptic plasticity

Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6644-9. doi: 10.1073/pnas.1016928108. Epub 2011 Apr 4.

Abstract

Adult neurogenesis is a process by which the brain produces new neurons once development has ceased. Adult hippocampal neurogenesis has been linked to the relational processing of spatial information, a role attributed to the contribution of newborn neurons to long-term potentiation (LTP). However, whether newborn neurons also influence long-term depression (LTD), and how synaptic transmission and plasticity are affected as they incorporate their network, remain to be determined. To address these issues, we took advantage of a genetic model in which a majority of adult-born neurons can be selectively ablated in the dentate gyrus (DG) and, most importantly, in which neurogenesis can be restored on demand. Using electrophysiological recordings, we show that selective reduction of adult-born neurons impairs synaptic transmission at medial perforant pathway synapses onto DG granule cells. Furthermore, LTP and LTD are largely compromised at these synapses, probably as a result of an increased induction threshold. Whereas the deficits in synaptic transmission and plasticity are completely rescued by restoring neurogenesis, these synapses regain their ability to express LTP much faster than their ability to express LTD. These results demonstrate that both LTP and LTD are influenced by adult neurogenesis. They also indicate that as newborn neurons integrate their network, the ability to express bidirectional synaptic plasticity is largely improved at these synapses. These findings establish that adult neurogenesis is an important process for synaptic transmission and bidirectional plasticity in the DG, accounting for its role in efficiently integrating novel incoming information and in forming new memories.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Dentate Gyrus / metabolism*
  • Dentate Gyrus / pathology
  • Female
  • Long-Term Potentiation*
  • Male
  • Memory
  • Mice
  • Mice, Transgenic
  • Neurogenesis*
  • Neurons / metabolism*
  • Neurons / pathology
  • Synapses / genetics
  • Synapses / metabolism*
  • Synapses / pathology
  • Synaptic Transmission*