1 Université de Bordeaux, Bordeaux, France; SANPSY, CNRS USR 3413, Bordeaux, France; Département (Pôle) Addictologie, CH Charles Perrens and CHU de Bordeaux, Bordeaux, France; Center for Studies of Addiction, Department of psychiatry, Perelman School of Medicine, University of Pennsylvania, Phildelphia, PA, USA. marc.auriacombe@u-bordeaux.fr.