Synapses let loose for a change: inhibitory synapse pruning throughout experience-dependent cortical plasticity

Frédéric Gambino; Anthony Holtmaat

doi:10.1016/j.neuron.2012.04.005

Synapses let loose for a change: inhibitory synapse pruning throughout experience-dependent cortical plasticity

Neuron. 2012 Apr 26;74(2):214-7. doi: 10.1016/j.neuron.2012.04.005.

Authors

Frédéric Gambino¹, Anthony Holtmaat

Affiliation

¹ Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

PMID: 22542175
DOI: 10.1016/j.neuron.2012.04.005

Abstract

In this issue of Neuron, Chen et al. (2012) and van Versendaal et al. (2012) used fluorescently tagged gephyrin to track inhibitory synapses in the mouse visual cortex in vivo. Their studies show that visual experience-dependent plasticity is associated with clustered and location-specific pruning of inhibitory synapses.

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