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Darnaudéry, Rincel et Lépinay dans Transl. Psychiatry

Un régime maternel riche en lipides protège le cerveau contre le stress

Le 29 mars 2017

Maternal high-fat diet prevents developmental programming by early-life stress. Rincel M, Lépinay AL, Delage P, Fioramonti J, Théodorou VS, Layé S, Darnaudéry M. Transl Psychiatry. 2016 Nov 29;6(11):e966

INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France.
Muriel Darnaudery: Team Psychoneuroimmunology and Nutrition: experimental and clinical approaches/ 
Université de Bordeaux, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France. INRA, Toxalim, UMR1331, Toulouse, France.

 Muriel Darnaudery: Early-life stress is associated with increased vulnerability to neuropsychiatric diseases later in life.
Similarly, obesity, excessive weight gain, metabolic disorders and unhealthy high-fat diet (HFD) during pregnancy have been recently hypothesized to increase the incidence of mental health disorders. Here, we examine whether maternal HFD can have effects similar to maternal separation (MS) and/or can exacerbate the effects of MS in the offspring.
Our results reveal that maternal HFD alleviates MS-induced endophenotypes in adult offspring, reduces maternal anxiety and increases maternal care in stressed dams. Contrary to the prevailing belief that HFD exposure is detrimental for the developing brain, our results suggest that obesity, rather than fat consumption per se, is critical for brain vulnerability.
Finally, although maternal HFD prevents stress-induced emotional alterations, it is important to consider other health outcomes, such as effects on metabolic or cardiovascular diseases. Accordingly, we recently demonstrated that maternal HFD combined with MS exacerbates later susceptibility to gain weight under HFD in offspring (Romaní-Pérez M, Lépinay AL, Alonso L, Rincel M, Xia L, Fanet H, Caillé S, Cador M, Layé S, Vancassel S, Darnaudéry M. Impact of perinatal exposure to high-fat diet and stress on responses to nutritional challenges, food-motivated behaviour and mesolimbic dopamine function. Int J Obes (Lond). 2017 Jan 24. )


Muriel Darnaudery /Professor of Neuroscience University Bordeaux/ lab NutriNeurO /UMR INRA 1286 (muriel.darnaudery @
Dernière mise à jour le 31.03.2017