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Daniela Cota & Giovanni Marsicano: nouvelle revue

Astroglial CB1 cannabinoid receptor regulate leptin signaling in mouse brain astrocytes

Le 21 octobre 2013

Elsevier Launches New Open Access Journal: Molecular Metabolism

Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes

Barbara Bosier, Luigi Bellocchio, Mathilde Metna-Laurent, Edgar Soria-Gomez, Isabelle Matias, Etienne Hebert-Chatelain, Astrid Cannich, Marlène Maitre, Thierry Leste-Lasserre, Pierre Cardinal, Juan Mendizabal-Zubiaga, Miren Josune Canduela, Leire Reguero, Emmanuel Hermans, Pedro Grandes, Daniela Cota, Giovanni Marsicano
Molecular Metabolism, published online 12 August 2013.

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Abstract (open-access article )

Type-1 cannabinoid (CB1) and leptin (ObR) receptors regulate metabolic and astroglial functions, but the potential links between the two systems in astrocytes were not investigated so far. Genetic and pharmacological manipulations of CB1 receptor expression and activity in cultured cortical and hypothalamic astrocytes demonstrated that cannabinoid signaling controls the levels of ObR expression. Lack of CB1 receptors also markedly impaired leptin-mediated activation of signal transducers and activators of transcription 3 and 5 (STAT3 and STAT5) in astrocytes. In particular, CB1 deletion determined a basal overactivation of STAT5, thereby leading to the downregulation of ObR expression, and leptin failed to regulate STAT5-dependent glycogen storage in the absence of CB1 receptors. These results show that CB1 receptors directly interfere with leptin signaling and its ability to regulate glycogen storage, thereby representing a novel mechanism linking endocannabinoid and leptin signaling in the regulation of brain energy storage and neuronal functions.

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Giovanni Marsicano
Researcher PhD
Team leader - Endocannabinoids and neuroadaptation
Neurocentre Magendie INSERM U862
Physiopathologie de la plasticité neuronale
Université Bordeaux 2